Dec 4, 2019

Post-trial low dose apomorphine prevents the development of morphine sensitization

Behavioural Brain Research
João Marcos de Mello BastosMarinete Pinheiro Carrera

Abstract

The development of sensitization is one of the hallmarks of addictive drugs. Consistent with this relationship many studies have demonstrated that the highly addictive opioid agonist morphine induces sensitization effects. In this study, we administered morphine (10 mg/kg) (MOR) to induce sensitization. In that sensitization is considered to involve associative processes and that dopamine activity is an important contributor to learning and memory processes, we administered a dopamine inhibitory treatment using apomorphine (0.05 mg/kg) (APO) during memory consolidation following a morphine sensitization treatment protocol. Seemingly, a decrease in dopamine activity during consolidation would impair the salience of the association of the morphine response with the contextual cues during consolidation and interfere with the development of morphine sensitization. In two separate experiments, MOR or vehicle (VEH) were administered pre-trial and either VEH or APO were administered post-trial over 5 and 10 days of treatment, respectively. In both the 5 and 10 drug treatment sessions post-trial experiments, MOR groups given VEH immediately post-trial exhibited strong sensitization effects. These sensitization effects were substantiall...Continue Reading

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Mentioned in this Paper

Study
Treatment Protocols
Trial Study
Drug Vehicle
Tnfrsf25 protein, mouse
Lung Consolidation
Dopamine
Drug Interactions
Receptors, Opioid, mu
Pharmacotherapy

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