PMID: 9181632May 1, 1997Paper

Post-weaning housing conditions influence the behavioural effects of cocaine and d-amphetamine

Psychopharmacology
J K SmithB Costall

Abstract

Post-weaning social isolation can induce profound and long lasting effects on an animal's behaviour. The present study investigated the influence of post-weaning housing conditions on the sensitivity of rats to the behavioural effects of d-amphetamine and cocaine. The locomotor stimulant effects of both drugs were compared following acute and chronic administration. The influence of post-weaning housing conditions on the effects of d-amphetamine and cocaine on responding for food and for a conditioned reinforcer were also examined. Isolated rats showed enhanced locomotor activity on exposure to a novel environment. This difference was further exaggerated following administration of d-amphetamine (0.5 mg/kg) and cocaine (5 mg/kg). Isolated, but not enriched, rats exhibited sensitisation to the locomotor activating effects of repeated administration of a dose of 0.5 mg/kg d-amphetamine, whilst both groups sensitised equally to a dose of 1.0 mg/kg d-amphetamine. Rearing conditions did not affect sensitisation to cocaine (5, 10 mg/kg). Isolated rats exhibited a higher rate of responding for a conditioned stimulus and for food on a progressive ratio schedule of reinforcement, both of which were enhanced to a greater extent in isolat...Continue Reading

Citations

May 11, 2013·Psychological Medicine·D VealeL Cardozo
Jun 1, 1999·The International Journal of Eating Disorders·E A SpringerC B Taylor
Mar 1, 2000·The International Journal of Eating Disorders·R H Striegel-MooreD E Wilfley
Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Jun 30, 2001·The International Journal of Eating Disorders·R H Striegel-MooreC G Fairburn
Jun 3, 2005·Bioelectromagnetics·A W PreeceK Wesnes
Jan 30, 2002·Depression and Anxiety·Merry N MillerGeorge R Brown
Mar 29, 2002·The International Journal of Eating Disorders·Victor R PendletonJohn P Foreyt
Mar 29, 2002·The International Journal of Eating Disorders·Kamryn T EddyDavid B Herzog
Sep 5, 2002·The International Journal of Eating Disorders·Debra L SaferW Stewart Agras
Apr 4, 2001·The International Journal of Eating Disorders·M F ZabinskiC B Taylor
Jul 13, 2001·The International Journal of Eating Disorders·M F ZabinskiC B Taylor
Feb 9, 2002·The International Journal of Eating Disorders·Nancy C RaymondPaul Thuras
Apr 27, 2005·The International Journal of Eating Disorders·Evelyn Attia, Laura Schroeder
Mar 5, 2008·Psychopharmacology·Susanna PietropaoloBenjamin K Yee
Oct 3, 2009·Psychopharmacology·Bruno Ribeiro Do CoutoJose Miñarro
Aug 3, 2005·Journal of Neural Transmission·K PapanikolaouZ Papadopoulou-Daifoti
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·Andreas LengBoris Ferger
Sep 25, 1999·Physiology & Behavior·V P Bakshi, M A Geyer
Mar 29, 2001·Pharmacology, Biochemistry, and Behavior·W F Caul, N A Brindle
Feb 26, 1998·Pharmacology, Biochemistry, and Behavior·J K SmithB Costall
Jul 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Molina-HernandezJ Perez-Garcia
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anne Michel, Ezio Tirelli
Sep 11, 2007·Psychological Medicine·P K KeelD C Jimerson
Dec 3, 2009·Psychological Medicine·J DunaiS L Rossell
May 12, 2011·Psychological Medicine·J D FeusnerT D Moody
May 11, 2013·CNS Spectrums·Katharine A PhillipsDan J Stein
Apr 13, 2012·Behavioural and Cognitive Psychotherapy·Georgina KrebsDavid Mataix-Cols
Jul 5, 2013·Behavioural and Cognitive Psychotherapy·David VealeTom Werner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.