Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats.

Physiology & Behavior
Jodi L LukkesChristopher A Lowry

Abstract

Previous studies have found that adolescent social isolation of rats can lead to an increased anxiety state during adulthood, while chronic anxiety states are associated with dysregulated local GABAergic inhibition within the basolateral amygdala (BL). Therefore, we investigated the effects of post-weaning social isolation of female rats, in combination with a challenge with the anxiogenic drug, N-methyl-beta-carboline-3-carboxamide (FG-7142), on a subset of GABAergic interneurons in the BL in adulthood using dual immunohistochemical staining for c-Fos and parvalbumin. Juvenile female rats were reared in isolation or in groups of three for a 3-week period from weaning to mid-adolescence, after which all rats were group-housed for an additional 2 weeks. Group-reared rats and isolation-reared rats injected with FG-7142 had increased c-Fos expression in GABAergic interneurons in the anterior part of the BL compared to group-reared rats and isolation-reared rats, respectively, injected with vehicle. Isolation rearing had a main effect to decrease c-Fos expression in GABAergic interneurons in the anterior part of the BL compared to group-reared rats. These data suggest that post-weaning social isolation of female rats leads to dysre...Continue Reading

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Citations

Apr 17, 2013·Pflügers Archiv : European journal of physiology·Nina C Donner, Christopher A Lowry
Mar 1, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wei Zhang, J Amiel Rosenkranz
Feb 14, 2013·Neuroscience·J L LukkesC A Lowry
Jan 29, 2014·Pharmacology, Biochemistry, and Behavior·Raffaella AlòMarcello Canonaco
Oct 22, 2017·Developmental Neurobiology·Elsa L Aguirre-BenítezJesús Hernández-Falcón
Apr 10, 2018·Experimental & Molecular Medicine·Olga BabaevDilja Krueger-Burg
Aug 30, 2018·Frontiers in Neuroscience·Fan JieBingjin Li
Jan 31, 2021·Developmental Cognitive Neuroscience·Kelsea R GildawieHeather C Brenhouse
Feb 23, 2018·Journal of Psychiatric Research·Jodi L LukkesSusan L Andersen

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