Postantibiotic and bactericidal effect of imipenem against Pseudomonas aeruginosa

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
I OdenholtO Cars

Abstract

The postantibiotic effect of imipenem on Pseudomonas aeruginosa was studied at different inocula using one ATCC strain and four clinical isolates. The postantibiotic effect was measured using two different methods: viable counts and bioluminescence assay of intracellular bacterial ATP. The postantibiotic effect could be demonstrated with both methods (viable counts 1-2 h, ATP assay 3-5 h) for all strains at an inoculum of 10(6) CFU/ml. When the inoculum was raised to 10(8) CFU/ml, no postantibiotic effect could be observed with either method using routine growth conditions. This disappearance of the postantibiotic effect coincided with a loss of bactericidal effect of imipenem when high inocula were used. Improved oxygenation of the cultures restored the bactericidal and postantibiotic effects of imipenem at high inocula.

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Citations

Nov 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H HanbergerR Maller
May 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H HanbergerM Nilsson
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Sep 1, 1991·Antimicrobial Agents and Chemotherapy·I Odenholt-TornqvistO Cars
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Jun 14, 2018·International Journal of Environmental Research and Public Health·Rutuja DhawdeTannaz Birdi
Jan 1, 1995·Scandinavian Journal of Infectious Diseases·F FuentesJ Prieto
May 21, 1998·Antimicrobial Agents and Chemotherapy·M GottfredssonS Gudmundsson

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