Postchemotherapy characteristics of hepatic colorectal metastases: remnants of uncertain malignant potential.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Tamara L ZnajdaPeter Metrakos

Abstract

Accepted management for colorectal cancer (CRC) involves resection of the primary neoplasm and chemotherapy; the debate continues over the most beneficial order of these components. Preoperative chemotherapy aimed at liver metastases may result in complete pathologic response and replacement of the malignancy with scar. The McGill University liver diseases database was retrospectively reviewed. Forty-one patients receiving treatment between December 2003 and August 2004 were identified, their medical records examined, and liver histology reviewed. The histology of the remnants was linked to the appearance of the lesions on preresection imaging and to the primary colorectal neoplasms. Twenty-seven of the 41 patients (66%) received preoperative chemotherapy (oxaliplatin or irinotecan). Features of the primary neoplasm that predicted resolution of the metastases were absence of tumor budding (P = 0.04), absence of a diffusely infiltrative tumor margin (P = 0.02), and loss of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase (P = 0.08). Oxaliplatin and irinotecan demonstrate beneficial effects in treating hepatic colorectal metastases and should be considered in such patients before resection. We propose the ...Continue Reading

References

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Citations

Feb 25, 2009·European Radiology·Philip J A Robinson
Jul 2, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Gabriel ChanPeter Metrakos
May 25, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Prosanto ChaudhuryPeter Metrakos
Oct 6, 2010·Advances in Surgery·Susanne Carpenter, Yuman Fong
Feb 24, 2009·Journal of Surgical Oncology·Dietmar TamandlThomas Gruenberger
Apr 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·René AdamDenis Castaing
Apr 6, 2012·Annals of Surgical Oncology·George A PoultsidesMichael I D'Angelica
Jan 20, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alessandro FerreroLorenzo Capussotti

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