Postchemotherapy retroperitoneal lymph node dissection is effective therapy in selected patients with elevated tumor markers after primary chemotherapy alone

Urology
C L CooganJohn P Donohue

Abstract

Elevated tumor markers after primary chemotherapy for metastatic testis cancer are usually an indication of persistent cancer. Subsequent treatment has usually been salvage chemotherapy. This article examines the possibility that selected patients can achieve long-term disease-free survival with surgery alone. Using a computerized data base of 627 postinduction chemotherapy retroperitoneal lymph node dissections (PC-RPLND), 23 patients with elevated tumor markers who have undergone PC-RPLND after induction chemotherapy alone were identified. Of the 23 patients, 15 were considered candidates for salvage chemotherapy, but instead underwent salvage surgery. Case histories were reviewed to establish selection criteria for PC-RPLND. Eight patients originally presented as clinical Stage C, 6 as clinical Stage B-3, and 1 as clinical Stage B-2. All patients initially received cisplatin combination chemotherapy. Twelve patients had an elevated alpha-fetoprotein level and 3 patients had an elevated beta human chorionic gonadotropin level prior to PC-RPLND. Seven patients had rising markers at the time of PC-RPLND. Seven patients had teratoma only in their resected specimen and all have no evidence of disease (NED) at a median of 35 month...Continue Reading

References

Jun 4, 1987·The New England Journal of Medicine·S D WilliamsP J Loehrer
Mar 1, 1996·The Journal of Urology·I LeibovitchJ P Donohue

❮ Previous
Next ❯

Citations

Jul 28, 2011·International Journal of Andrology·D KoychevF Honecker
Jul 6, 2004·Clinical Biochemistry·Ulf-Håkan StenmanKristina Hotakainen
Nov 28, 2015·Surgical Pathology Clinics·Brandon Bernard, Christopher J Sweeney
May 9, 2007·The Urologic Clinics of North America·Hong Gee SimDaniel W Lin
May 9, 2007·The Urologic Clinics of North America·Stephen D W BeckJohn P Donohue
Feb 8, 2006·Cancer·Christian KollmannsbergerCarsten Bokemeyer
Aug 20, 2008·Expert Opinion on Pharmacotherapy·C KollmannsbergerC Bokemeyer
Apr 11, 2015·Urologic Oncology·Siamak Daneshmand
Dec 21, 2010·Expert Review of Anticancer Therapy·Michael C Risk, Richard S Foster
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jan OldenburgSophie D Fossa
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen D W BeckJohn P Donohue
Dec 22, 2004·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Salwa El SayedHorácio A Moreira
Mar 9, 2018·Expert Review of Anticancer Therapy·Christoph OingCarsten Bokemeyer
Aug 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J SchmollUNKNOWN European Germ Cell Cancer Consensus Group
Jul 14, 2018·Current Opinion in Urology·Jale LakesPeter Albers
Jul 28, 2016·World Journal of Urology·Christoph OingCarsten Bokemeyer
Sep 9, 2010·Urologic Oncology·Yaron EhrlichLawrence H Einhorn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.