Postconditioning and intermittent bradykinin induced cardioprotection require cyclooxygenase activation and prostacyclin release during reperfusion

Basic Research in Cardiology
C PennaPasquale Pagliaro

Abstract

Postconditioning (PostC), obtained with brief intermittent cycles of ischemia alternating with reperfusion applied after the ischemic event, has been shown to reduce infarct size. Recently, we have shown that PostC triggering includes B2 receptor activation and its downstream pathway. Moreover, we showed that BK intermittent infusion induces a cardioprotection similar to PostC. The aim of this study was to investigate the involvement of cyclooxygenase-(COX)-derivated prostaglandins, such as prostacyclin (PGI2) pathway in the cardioprotective action mediated by intermittent BK infusion. Isolated rat hearts underwent 30 min ischemia and 120 min reperfusion. Myocardial damage was evaluated using nitro-blue-tetrazolium staining. The production of metabolite of PGI2, 6-keto-PGF1alpha, was evaluated with EIA assay on the samples collected during reperfusion. The perfusion pressure and the left ventricular pressure were monitored. In Control hearts, the infarct size was 64% +/- 4% of risk area. PostC reduced significantly the infarct size (28% +/- 4% P < 0.001 Vs. Control). BK intermittent protocol to mimic PostC, attenuated infarct size (40% +/- 2% P < 0.01 Vs. Control). The BK-intermittent and PostC protections were abolished with C...Continue Reading

References

Feb 1, 1988·Circulation Research·N E FarberG J Gross
Jun 24, 1989·Molecular and Cellular Biochemistry·M van BilsenR S Reneman
Sep 14, 1999·Journal of the American College of Cardiology·M A LeesarR Bolli
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R RastaldoP Pagliaro
Aug 6, 2002·Cardiovascular Research·Petra GresGerd Heusch
Dec 25, 2002·Free Radical Biology & Medicine·Pasquale PagliaroNazareno Paolocci
Jul 16, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zhi-Qing ZhaoJakob Vinten-Johansen
Sep 5, 2003·Basic Research in Cardiology·A LochnerJ A Moolman
Sep 1, 2004·The Annals of Thoracic Surgery·Michael E HalkosZhi-Qing Zhao
Mar 29, 2005·Basic Research in Cardiology·J Vinten-JohansenF Kerendi
May 12, 2005·Trends in Cardiovascular Medicine·Derek J HausenloyDerek M Yellon
Jun 14, 2005·Cardiovascular Research·Hajime KinJakob Vinten-Johansen
Sep 28, 2005·Circulation·Patrick StaatMichel Ovize
Oct 19, 2005·British Journal of Pharmacology·Ulrich HilgenfeldtSabina Lewicka
Oct 19, 2005·British Journal of Pharmacology·Xiuxin LiuUlrich Hilgenfeldt
Jan 6, 2006·The Journal of Clinical Investigation·Tilo GrosserGarret A FitzGerald
Feb 14, 2006·Lancet·Derek M Yellon, Lionel H Opie
Mar 21, 2006·Cardiovascular Research·Zhi-Qing Zhao, Jakob Vinten-Johansen
Mar 21, 2006·Cardiovascular Research·Sebastian PhilippMichael V Cohen
Mar 29, 2006·Basic Research in Cardiology·Gerd HeuschRainer Schulz
Sep 28, 2006·Basic Research in Cardiology·James MykytenkoZhi-Qing Zhao
Jun 5, 2007·Basic Research in Cardiology·Vivek SivaramanDerek M Yellon
Jun 15, 2007·Journal of Cardiovascular Pharmacology and Therapeutics·Joan Dow, Robert A Kloner
Aug 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hiroshi SatoXian-Liang Tang
Oct 31, 2007·Circulation Research·Kerstin BoenglerRainer Schulz

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Citations

May 27, 2008·Basic Research in Cardiology·Jason N PeartGarrett J Gross
Nov 26, 2008·Basic Research in Cardiology·Wen ZhaoEvangelia G Kranias
May 23, 2009·Basic Research in Cardiology·Shiang Y LimChristopher C T Smith
Jun 23, 2009·Basic Research in Cardiology·Andreas SkyschallyGerd Heusch
Nov 26, 2010·Cellular and Molecular Neurobiology·Claudia PennaPasquale Pagliaro
Jul 24, 2010·Antioxidants & Redox Signaling·Pasquale PagliaroClaudia Penna
Jul 14, 2010·Antioxidants & Redox Signaling·Jakob Vinten-JohansenKarin Przyklenk
May 8, 2010·Cardiovascular Research·Michel OvizeUNKNOWN Working Group of Cellular Biology of Heart of European Society of Cardiology
May 19, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Garrett J GrossKasem Nithipatikom
Aug 1, 2008·Expert Review of Cardiovascular Therapy·Umar SadatKevin Varty
Jul 27, 2014·International Journal of Cardiology·Junping SunYutao Xi
Aug 13, 2008·The Journal of Surgical Research·Claudia PennaPasquale Pagliaro
Nov 6, 2013·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yuji MaruyamaMasami Ochi
Mar 3, 2009·Biochimica Et Biophysica Acta·Claudia PennaPasquale Pagliaro
Mar 31, 2009·Biochimica Et Biophysica Acta·Claudia PennaPasquale Pagliaro
Dec 26, 2008·Current Opinion in Pharmacology·Dwaine S Burley, Gary F Baxter
Feb 16, 2013·Journal of Cardiovascular Medicine·Jakob Vinten-Johansen, Weiwei Shi
Feb 27, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Jan StumpnerThorsten Smul
Jun 6, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Yumei YeYochai Birnbaum
May 4, 2010·American Journal of Physiology. Heart and Circulatory Physiology·K T KeyesY Birnbaum
Oct 11, 2014·British Journal of Pharmacology·P Pagliaro, C Penna
Jan 2, 2020·Antioxidants & Redox Signaling·Claudia PennaAntonio Crisafulli
Apr 29, 2020·International Journal of Molecular Sciences·Alessandro BellisCarmine Morisco
May 13, 2020·Neural Regeneration Research·Zhi-Gang LiuXiao-Yu Yang
Aug 18, 2021·Cardiovascular Drugs and Therapy·Yochai BirnbaumYumei Ye

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