Postconditioning with simvastatin decreases myocardial injury in rats following acute myocardial ischemia

Experimental and Therapeutic Medicine
Heng-Chen YaoMei Zhang

Abstract

The aim of the present study was to investigate whether postconditioning with simvastatin attenuated myocardial ischemia reperfusion injury by inhibiting the expression of high mobility group box 1 (HMGB1) in rat myocardium following acute myocardial ischemia. In total, 30 male Sprague-Dawley rats were divided into sham operation (sham; n=10), acute myocardial infarction (AMI; n=10) and simvastatin (sim; n=10) groups. The AMI and sim groups were subjected to ischemia for 30 min, followed by reperfusion for 180 min. The rats in the sim group were administered 20 mg/kg simvastatin intravenously 5 min prior to reperfusion. Subsequently, the infarct size, serum cardiac troponin (c-TnI), tumor necrosis factor (TNF)-α and myocardial malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity were measured. Western blot analysis was used to detect the protein expression of HMGB1. Postconditioning with simvastatin was shown to decrease the infarct size and HMGB1 expression levels in the myocardium following AMI (P<0.05). In addition, postconditioning with simvastatin not only decreased the serum levels of c-TnI and TNF-α (P<0.05), but also inhibited the increase in MDA levels and the reduction in SOD activity (P<0.05). Therefo...Continue Reading

References

Nov 1, 1985·The Journal of Clinical Investigation·E Braunwald, R A Kloner
Oct 9, 2003·The EMBO Journal·Tiziana BonaldiMarco E Bianchi
Jul 11, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D RenS Wang
Dec 11, 2007·Trends in Molecular Medicine·Chao-Yung WangJames K Liao
Dec 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Hui ChenZhiyuan Chen
Jun 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Susumu OozawaShunji Sano
Nov 19, 2009·Journal of Translational Medicine·Shaheen E LakhanMagdalena Hofer
Jun 10, 2010·Cardiovascular Drugs and Therapy·Zhi-Qing Zhao
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Jun 9, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anders Riegels KnudsenFrank Viborg Mortensen

❮ Previous
Next ❯

Citations

Jan 18, 2016·International Journal of Cardiology·Xiao-Yan MengHeng-Chen Yao
Nov 5, 2017·Biochemical Society Transactions·Bernd Gesslbauer, Valery Bochkov
Oct 3, 2017·International Heart Journal·Rungtiwa SrisuwanthaJun-Ichi Suzuki
Jan 4, 2017·Journal of Nephropathology·Zahra GoodarziMassumeh Ahmadizadeh

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
protein assay

Software Mentioned

SAS
Image
Pro Plus

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.