Abstract
The aim of the present study was to investigate whether postconditioning with simvastatin attenuated myocardial ischemia reperfusion injury by inhibiting the expression of high mobility group box 1 (HMGB1) in rat myocardium following acute myocardial ischemia. In total, 30 male Sprague-Dawley rats were divided into sham operation (sham; n=10), acute myocardial infarction (AMI; n=10) and simvastatin (sim; n=10) groups. The AMI and sim groups were subjected to ischemia for 30 min, followed by reperfusion for 180 min. The rats in the sim group were administered 20 mg/kg simvastatin intravenously 5 min prior to reperfusion. Subsequently, the infarct size, serum cardiac troponin (c-TnI), tumor necrosis factor (TNF)-α and myocardial malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity were measured. Western blot analysis was used to detect the protein expression of HMGB1. Postconditioning with simvastatin was shown to decrease the infarct size and HMGB1 expression levels in the myocardium following AMI (P<0.05). In addition, postconditioning with simvastatin not only decreased the serum levels of c-TnI and TNF-α (P<0.05), but also inhibited the increase in MDA levels and the reduction in SOD activity (P<0.05). Therefo...Continue Reading
References
Nov 1, 1985·The Journal of Clinical Investigation·E Braunwald, R A Kloner
Oct 9, 2003·The EMBO Journal·Tiziana BonaldiMarco E Bianchi
Jul 11, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D RenS Wang
Dec 16, 2006·Circulation Research·Andreas SkyschallyGerd Heusch
Nov 7, 2007·The Journal of Experimental Medicine·Allan TsungTimothy R Billiar
Dec 11, 2007·Trends in Molecular Medicine·Chao-Yung WangJames K Liao
Dec 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Hui ChenZhiyuan Chen
Jun 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Susumu OozawaShunji Sano
Nov 19, 2009·Journal of Translational Medicine·Shaheen E LakhanMagdalena Hofer
Nov 26, 2009·Circulation·Abhiram PrasadBernard Gersh
Nov 26, 2009·Anesthesiology·Xiaojing JiangHong Ma
Apr 22, 2010·European Journal of Pharmacology·Xiaorong HuHong Jiang
Jun 10, 2010·Cardiovascular Drugs and Therapy·Zhi-Qing Zhao
Oct 6, 2010·Clinical Science·Qian FanZhengyuan Xia
Mar 3, 2011·Journal of Internal Medicine·M AndrassyG Korosoglou
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Jun 9, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anders Riegels KnudsenFrank Viborg Mortensen
Jul 24, 2012·International Journal of Cardiology·Xiang-Dong LiRun-Lin Gao
Oct 31, 2012·Molecular Biology Reports·Haidong LiangChunsheng Wang
Feb 8, 2013·Neurochemical Research·Yuhan KongXinyue Qin
Mar 28, 2013·Coronary Artery Disease·Dan KeLianglong Chen
May 23, 2013·Heart, Lung & Circulation·Heng-Chen YaoLe-Xin Wang
Jun 4, 2013·Gene·Hua-Sheng DingQin-Qin Yu
Aug 13, 2013·Experimental and Therapeutic Medicine·Heng-Chen YaoLE-Xin Wang
Dec 19, 2013·Experimental and Therapeutic Medicine·Xianjin DUJie Wei
Mar 19, 2014·PloS One·Katsunori KitanoMasayuki Takamura
Oct 11, 2014·Gene·Qi-Feng CaoSong-Bo Di
Citations
Jan 18, 2016·International Journal of Cardiology·Xiao-Yan MengHeng-Chen Yao
Apr 8, 2015·International Journal of Cardiology·Rui-Jie GaoHeng-Chen Yao
May 8, 2016·Transplant Immunology·Raimo TuuminenKarl B Lemström
Nov 5, 2017·Biochemical Society Transactions·Bernd Gesslbauer, Valery Bochkov
Dec 10, 2015·Molecular Medicine Reports·Heng-Chen YaoMei Zhang
Aug 16, 2017·Experimental and Therapeutic Medicine·Yan-Hong ZhouDe-Yong Zhang
Oct 3, 2017·International Heart Journal·Rungtiwa SrisuwanthaJun-Ichi Suzuki
Feb 18, 2020·Frontiers in Physiology·Yan-Hong ZhouHeng-Chen Yao
Dec 2, 2015·Experimental and Therapeutic Medicine·Ren Rong, Xiao Xijun
Jan 4, 2017·Journal of Nephropathology·Zahra GoodarziMassumeh Ahmadizadeh