Postcranioplasty seizures following decompressive craniectomy and seizure prophylaxis: a retrospective analysis at a single institution

Journal of Neurosurgery
Mun-Chun YeapPo-Hsun Tu

Abstract

Cranioplasty is a relatively simple and less invasive intervention, but it is associated with a high incidence of postoperative seizures. The incidence of, and the risk factors for, such seizures and the effect of prophylactic antiepileptic drugs (AEDs) have not been well studied. The authors' aim was to evaluate the risk factors that predispose patients to postcranioplasty seizures and to examine the role of seizure prophylaxis in cranioplasty. The records of patients who had undergone cranioplasty at the authors' medical center between 2009 and 2014 with at last 2 years of follow-up were retrospectively reviewed. Demographic and clinical characteristics, the occurrence of postoperative seizures, and postoperative complications were analyzed. Among the 583 patients eligible for inclusion in the study, 247 had preexisting seizures or used AEDs before the cranioplasty and 336 had no seizures prior to cranioplasty. Of these 336 patients, 89 (26.5%) had new-onset seizures following cranioplasty. Prophylactic AEDs were administered to 56 patients for 1 week after cranioplasty. No early seizures occurred in these patients, and this finding was statistically significant (p = 0.012). Liver cirrhosis, intraoperative blood loss, and shu...Continue Reading

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Citations

Feb 2, 2021·Acta neurochirurgica·Dorian HirschmannChristian Dorfer
Oct 8, 2020·Respiratory Medicine Case Reports·Shintaro SatoHidekazu Matsushima
Jul 6, 2021·Surgical Neurology International·Ahmed AloraidiAhmed Alkhani
Dec 14, 2019·Journal of Neurosurgery·Guru Dutta Satyarthee, Luis R Moscote-Salazar

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