Postdonation iron replacement for maintaining iron stores in female whole blood donors in routine donor practice: results of two feasibility studies in Australia

Transfusion
Sant-Rayn PasrichaJoanna Speedy

Abstract

Iron deficiency represents a risk to donor health and the blood supply. Efficacy trials indicate that postdonation iron replacement improves iron stores but they do not account for complexities of implementation in the routine collection context. We therefore conducted two prospective feasibility studies in Australian donor centers. In both studies we recruited female donors between 18 and 45 years who had made at least one donation in the previous 12 months. In READ (replacement advice), female donors were given a recommendation to self-procure postdonation iron. In DIRECT (donor iron replacement), donors were provided with a course of iron supplements. Donors could return to donate at their discretion and were surveyed after the recruitment visit and again toward the end of the 13-month follow-up. Donor uptake, adverse effects, effectiveness in maintaining iron stores, and workflow impact were assessed. We recruited 1404 (70.9% of invited) donors to READ and 768 (53.2% of invited) to DIRECT. READ and DIRECT extended predonation interviews by 1 and 5 minutes, respectively. Among participants, 44 and 88% took iron in READ and DIRECT, respectively. Adverse effects were common but usually mild. READ failed to maintain iron stores...Continue Reading

References

Mar 9, 2007·The American Journal of Clinical Nutrition·Laura E Murray-Kolb, John L Beard
Nov 3, 2010·The Medical Journal of Australia·Sant-Rayn S PasrichaKathryn L Robinson
Oct 26, 2011·Transfusion·Ritchard G CableUNKNOWN NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II)
Apr 18, 2014·Transfusion·Hannah E SalvinJoanna Speedy
Jul 6, 2014·The Cochrane Database of Systematic Reviews·Graham A SmithDavid J Roberts
Feb 11, 2015·JAMA : the Journal of the American Medical Association·Joseph E KissUNKNOWN National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study–III (REDS-III)
Apr 19, 2016·The Cochrane Database of Systematic Reviews·Michael Sze Yuan LowSant-Rayn Pasricha
Dec 13, 2016·Transfusion·Mindy GoldmanSheila F O'Brien

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