Poster - Thur Eve - 15: Production and assessment of astatine-211 for targeted alpha therapy

Medical Physics
J CrawfordT Ruth

Abstract

Biologically-targeted alpha-particle radiation is the basis of new and promising treatments for eliminating disseminated micrometastases and the residual microscopic malignancies that remain after surgery or radiation therapy. The short-range alpha-particles are highly cytotoxic and capable of inactivating single, isolated cancer cells which may otherwise cause recurrence. Astatine-211 is a promising alpha emitter for therapy; the 7.2 hour half-life of (211) At provides sufficient time for biological-targeting to take place. However, this radionuclide is in short supply and future treatment strategies still require extensive preclinical evaluation. The present work aims to develop technologies that (1) increase the world-wide availability of (211) At for clinical use, and (2) assess the risks of (211) At-based therapies by quantifying the activity distributions in animal models. At TRIUMF (Vancouver, BC), the feasibility of a novel generator system for (211) At is under investigation which would allow distribution of (211) At across Canada and internationally. Briefly, a longer-lived parent radionuclide of (211) At, radon-211, would be produced and allowed to decay in containment to yield (211) At in solution. Additionally, a s...Continue Reading

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