Poster - Thurs Eve-11: Quantitative imaging of 213Bi alpha-emitter with a beta-imager

Medical Physics
R HobbsGeorge Sgouros

Abstract

Targeted alpha-particle emitter therapy is emerging as a promising approach for treating metastatic cancer. An understanding of the biodistribution of targeted alpha-emitters at the cell level is important in evaluating potential efficacy and toxicity. This is best accomplished by autoradiography of tissue samples, ex vivo. We have investigated the feasibility of using a high resolution, quantitative beta-imager (Biospace Mesures β-Imager) to detect the short-lived alpha-particle emitter, Bismuth-213 (213Bi). The advantages of this detector include: shorter acquisition time than film-based autoradiography, which is critical for an isotope with such a short half-life; high resolution; and data acquisition in list mode. While our interest in 213Bi lies in the α, the decay chain includes high energy β(-) particles, enabling this study. Published studies using the β-Imager show predominantly qualitative results, with the quantitative depending on long exposure time or direct comparisons. At low count rate the detector auto-regulates by varying the HV, directly affecting the results. We imaged a phantom prepared from 213Bi in 5% gelatin. We plot only the results in a narrow HV range and fit an exponential decay function to obtain a ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Roswitha HuberReingard Senekowitsch-Schmidtke
Neoplasia : an International Journal for Oncology Research
Jean-Baptiste GorinJoëlle Gaschet
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
G SulimanAlfred Morgenstern
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Deborah A MulfordJ G Jurcic
© 2022 Meta ULC. All rights reserved