Poster - Thurs Eve-20: Analysis of dosimetric differences between dose-to-water vs. dose-to-medium calculations for electron beams

Medical Physics
E GilJoanna E Cygler

Abstract

With the advent of commercial Monte Carlo based treatment planning systems (TPS) typically calculating dose-to-medium, Dm , as opposed to dose-to-water, Dw , calculated by conventional TPS, a thorough analysis of differences between these treatments plans is required. Such an analysis has not yet been carried out. The purpose of our study was to evaluate dosimetric differences between such plans generated with a commercial MC based TPS. The analysis included plans of 53 breast cancer patients treated with electron beams ranging from 6-20 MeV. These plans were originally calculated using the Dm approach. Keeping the original beam arrangements and the same calculation parameters, the plans were recalculated using the Dw approach. The comparison between Dm and Dw plans was performed by means of dose volume histograms and isodose distributions on the corresponding CT slices. The plans calculated using Dm vs. Dw show some differences, with magnitudes depending on the location of the tumor and organs at risk and the beam energy. The largest difference was found for the treatment of the chest wall after complete mastectomy with 13 MeV beam. The dose to internal mammary nodes was 43.6 Gy and 39.0 Gy for Dm and Dw approach, respectively...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.