Posterior Cerebellar Volume and Executive Function in Young Adults With Congenital Heart Disease

Journal of the International Neuropsychological Society : JINS
Eric S SemmelTricia Z King

Abstract

As the number of adolescents and young adults (AYAs) surviving congenital heart disease (CHD) grows, studies of long-term outcomes are needed. CHD research documents poor executive function (EF) and cerebellum (CB) abnormalities in children. We examined whether AYAs with CHD exhibit reduced EF and CB volumes. We hypothesized a double dissociation such that the posterior CB is related to EF while the anterior CB is related to motor function. We also investigated whether the CB contributes to EF above and beyond processing speed. Twenty-two AYAs with CHD and 22 matched healthy controls underwent magnetic resonance imaging and assessment of EF, processing speed, and motor function. Volumetric data were calculated using a cerebellar atlas (SUIT) developed for SPM. Group differences were compared with t tests, relationships were tested with Pearson's correlations and Fisher's r to z transformation, and hierarchical regression was used to test the CB's unique contributions to EF. CHD patients had reduced CB total, lobular, and white matter volume (d=.52-.99) and poorer EF (d=.79-1.01) compared to controls. Significant correlations between the posterior CB and EF (r=.29-.48) were identified but there were no relationships between the ...Continue Reading

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Citations

Jul 24, 2020·Cardiology in the Young·Adam R Cassidy
Jun 26, 2020·Cardiology in the Young·Alexander TanDawn Ilardi
Dec 30, 2020·Pediatric Cardiology·Melinda BarkhuizenAntonio W D Gavilanes
Jan 31, 2021·Neuropsychology Review·Sarah V ClarkTricia Z King
Jan 13, 2021·AJNR. American Journal of Neuroradiology·F Machado-RivasC Jaimes
Jan 31, 2021·Brain Imaging and Behavior·Nadja NaefRuth Tuura O'Gorman
Sep 26, 2021·Pediatrics·Maria FeldmannBeatrice Latal

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