Posterior Circulation Evaluation in Patients with Sickle Cell Anemia

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Samuel Ademola AdegokeGisele Sampaio Silva

Abstract

The role of transcranial Doppler (TCD) ultrasonography in identifying children with sickle cell anemia (SCA) at risk for stroke is well known; however, the major studies that evaluated TCD velocities in children with SCA did not report posterior circulation evaluation data. The objective of our study was to describe the pattern of blood flow velocities in the posterior circulation of patients with SCA and to examine their relationship with findings on magnetic resonance imaging (MRI)/magnetic resonance angiography (MRA). All adult patients with SCA followed in the outpatient clinic of our hospital were evaluated with TCD and MRI/MRA. The highest velocities of the middle cerebral arteries or internal carotid arteries were taken as the time-averaged maximum mean (TAMM) velocity for each patient and the maximum mean flow velocities in the posterior circulation (TAMMpost) were recorded. Fifty-six patients with SCA and 56 healthy nonanemic volunteers were evaluated. The mean TAMMpost in the basilar, vertebral, and posterior cerebral arteries (PCAs) were significantly higher among cases than controls (P < .01). In patients with SCA, the TAMMpost in all posterior circulation arteries had a positive correlation with TAMM. Only 1 patien...Continue Reading

References

Mar 11, 1998·Controlled Clinical Trials·R J AdamsM A Waclawiw
May 1, 2001·Archives of Neurology·R J Adams
May 31, 2003·Radiology·R Grant SteenKathleen J Helton
Apr 1, 2004·Blood·Heather J FullertonS Claiborne Johnston
Nov 12, 2005·Cerebrovascular Diseases·Gisele Sampaio SilvaAyrton Roberto Massaro
Jul 25, 2006·Blood·Margaret T LeeUNKNOWN STOP Study Investigators
Nov 14, 2007·Archives of Neurology·Robert J Adams
May 16, 2009·Stroke; a Journal of Cerebral Circulation·Gisele Sampaio SilvaAyrton Roberto Massaro
Jun 6, 2012·Journal of Biomedicine & Biotechnology·Tim Lekic, Chizobam Ani

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.