Abstract
The syndrome of posterior cortical atrophy (PCA) is a rare clinical manifestation of several neurodegenerative diseases which affect the parieto-occipital cortex. The most frequent underlying pathology is Alzheimer's disease but some cases are caused by Lewy body disease, progressive subcortical gliosis, corticobasal degeneration or prion diseases. The most prominent clinical feature of PCA is complex visual disturbances including object agnosia, simultanagnosia, optical ataxia and oculomotor apraxia while basic visual functions remain intact. These deficits lead to multiple impairments in activities of daily living that require visual control. On progression of the disease amnestic, apraxic and dysexecutive symptoms occur so that a global dementia gradually emerges. At the core of the diagnostic work-up are a detailed patient history, accurate analysis of behavior and neuropsychological testing. Structural and functional brain imaging are suitable to demonstrate the localization of the disease process. Measurement of cerebrospinal fluid proteins (e.g. beta amyloid, tau, phospho-tau and 14-3-3) serves to confirm or exclude Alzheimer's disease or prion diseases. The mainstay of treatment are non-pharmacological interventions to ...Continue Reading
References
Jul 1, 1988·Archives of Neurology·D F BensonB D Snyder
Aug 1, 1982·Annals of Neurology·H A CrystalS Jotkowitz
Jan 13, 1998·Vision Research·P R HofJ H Morrison
Jun 8, 2002·Dementia and Geriatric Cognitive Disorders·Mario F MendezKent M Perryman
Jul 27, 2004·Klinische Monatsblätter für Augenheilkunde·P WeberH J Kaiser
Oct 13, 2004·Neurology·D F Tang-WaiR C Petersen
Oct 13, 2004·Neurology·J A RennerJ C Morris
Nov 29, 2005·Clinical Neurology and Neurosurgery·Eunhee KimSeol-Heui Han
Jun 27, 2006·Neurobiology of Aging·Jennifer L WhitwellKeith A Josephs
May 31, 2007·American Journal of Alzheimer's Disease and Other Dementias·Luca RozziniAlessandro Padovani
Jul 3, 2007·CNS Spectrums·Giuseppe Vallar
Sep 28, 2007·Brain : a Journal of Neurology·S AlladiJ R Hodges
Oct 19, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Julie S SnowdenDavid Mann
Mar 23, 2010·Neuropsychological Rehabilitation·María RocaFacundo Manes
Aug 12, 2010·BMC Neurology·Katia AndradePaolo Bartolomeo
Apr 12, 2011·Brain : a Journal of Neurology·Aurélie KasMarie Sarazin
Apr 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Guy M McKhannCreighton H Phelps
Jun 28, 2011·Brain : a Journal of Neurology·Leonardo Cruz de SouzaMarie Sarazin
Jan 24, 2012·Lancet Neurology·Sebastian J CrutchNick C Fox
Jul 10, 2012·Annals of Physical and Rehabilitation Medicine·A Weill-ChounlamountryP Pradat-Diehl
Sep 19, 2012·Journal of Alzheimer's Disease : JAD·Emilie BeaufilsDenis Guilloteau
Mar 7, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Timo S SpehlLars Frings
Citations
Jan 9, 2018·Neurocase·Sol EstevesMaría Roca
Jun 18, 2019·Journal of Geriatric Psychiatry and Neurology·Georg C ZieglerAlexandra Herr
Mar 25, 2019·Der Nervenarzt·Julian ConradAdrian Danek
Nov 25, 2020·Acta neurologica Belgica·Gautam DasAtanu Biswas