Posterior extension of the chick nephric (Wolffian) duct: the role of fibronectin and NCAM polysialic acid

Developmental Dynamics : an Official Publication of the American Association of Anatomists
R BellairsJ W Lash

Abstract

The nephric duct of the chick embryo starts to form at about stage 10 of Hamburger and Hamilton ([1951] J. Morphol. 88:49-92) and extends posteriorly, fusing with the cloaca at about the end of the third day of incubation (HH stage 17). Evidence from the literature suggests that the extension involves active migration of the posterior tip. This investigation concerned some molecules that might control this migration: fibronectin, vitronectin, the beta 1 integrin receptor, and NCAM polysialic acid. The concentration of fibronectin in the extracellular matrix was found by immunocytochemistry to be negligible at the posterior end of the duct; treatment of the living embryo with GRGDS failed to halt further extension of the duct; SEM examination of embryos treated with the synthetic peptides of fibronectin GRGDS, GRDGS, SDGR, and GRGES, or with vitronectin, revealed negligible morphological effects on the duct. It is concluded that there is yet no evidence that fibronectin is an important factor in duct migration. NCAM polysialic acid had a similar distribution to fibronectin, but treatment of the living embryo with Endo-N caused cessation of extension of the duct. Endo-N is an enzyme that specifically degrades PSA without affectin...Continue Reading

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Citations

Apr 5, 2003·Bulletin of Mathematical Biology·K A LandmanD F Newgreen
Oct 1, 1996·Current Opinion in Cell Biology·U Rutishauser
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Abderrahman El MaaroufUrs Rutishauser
Dec 18, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lital AttiaThomas M Schultheiss
Oct 12, 2005·Developmental Biology·Anissa PedersenWilliam Shawlot
Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J W BrownS R Hilfer
Jan 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Julie DrawbridgeMary E Kite
Aug 18, 1995·The Journal of Biological Chemistry·S OkaU Rutishauser

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