Posterior fossa ependymoma: current insights

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Yuan Y ThompsonMichael D Taylor

Abstract

Ependymoma is the third most common malignant tumor of the posterior fossa and is a major cause of neurological morbidity and mortality in children. Current treatments, particularly surgery and external beam irradiation result in relatively poor outcomes with significant neurological and cognitive sequelae from treatment. Historical approaches have considered all ependymomas as similar entities based on their morphological appearance. Recent advances in genomics and epigenetics have revealed, however, that ependymomas from different CNS locations represent distinct entities. Moreover, ependymoma of the posterior fossa, the most common location in children, is actually comprised of two distinct molecular variants. These two variants have marked differences in demographics, transcriptomes, structure, methylation patterns, and clinical outcomes. This allows for the development of new biology-based clinical risk stratification, which can both prioritize patients for de-escalation of therapy and identify those who will benefit from novel therapeutic strategies. Indeed, the identification of these two variants allows an opportunity for robust preclinical modeling for development of novel therapeutic strategies. Herein, we have summar...Continue Reading

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Citations

Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vijay RamaswamyMichael D Taylor
Jun 18, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Scott RyallVijay Ramaswamy
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Feb 7, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Bahattin TanrıkuluM Memet Özek
Nov 17, 2016·Chinese Journal of Cancer·Vijay Ramaswamy, Michael D Taylor
Jul 19, 2018·Acta Neuropathologica·Florence M G CavalliVijay Ramaswamy
Sep 6, 2020·Journal of Medical Imaging and Radiation Sciences·Hannan EbrahimiMaysam Alimohamadi
Feb 3, 2021·The Neuroradiology Journal·Marco VarrassiCarlo Masciocchi
May 24, 2020·Cell·Kulandaimanuvel Antony MichealrajMichael D Taylor

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