Posterior hippocampal regional cerebral blood flow predicts abstinence: a replication study

Addiction Biology
Bryon AdinoffElliot A Stein

Abstract

The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuous arterial spin labeling magnetic resonance imaging, predicted days to cocaine relapse following residential treatment. In this secondary analysis, we explored whether rCBF in this same pHp region would successfully predict 30-day point prevalence abstinence 60 days following residential treatment in an independent group of previously studied participants with cocaine dependence. rCBF was assessed with single photon emission computerized tomography during a saline infusion in 21 cocaine dependence and 22 healthy control participants. pHp rCBF was significantly higher in those endorsing substance use (n = 10) relative to both abstinent (n = 11) (p < 0.001) and control (p < 0.05) participants. There were no significant differences in measured demographic or clinical variables between the actively using and non-using participants. This replicative finding suggests that heightened pHp activation is a significant predi...Continue Reading

References

Jun 1, 1966·Journal of Comparative and Physiological Psychology·R UrsinJ Olds
Sep 1, 1984·Behavioral and Neural Biology·T J Collier, A Routtenberg
Jan 19, 1999·The American Journal of Psychiatry·A R ChildressC P O'Brien
Nov 4, 2000·The American Journal of Psychiatry·H GaravanE A Stein
Apr 25, 2001·Archives of General Psychiatry·C D KiltsK P Drexler
Oct 29, 2002·Psychopharmacology·Yavin ShahamJane Stewart
Mar 26, 2003·Psychopharmacology·Peter W Kalivas, Krista McFarland
Sep 17, 2004·Neuroreport·Makoto SasakiAkira Ogawa
Jun 17, 2006·Annual Review of Neuroscience·Steven E HymanEric J Nestler
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hans S CrombagYavin Shaham
May 9, 2009·Psychological Science·Michael A SayetteJonathan W Schooler
Aug 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Francesca M FilbeyKent E Hutchison
Sep 25, 2009·Psychopharmacology·Kenzie L PrestonDavid H Epstein
Nov 27, 2009·Addictive Behaviors·David H EpsteinKenzie L Preston
Apr 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bryon AdinoffMunro Cullum
Feb 2, 2012·The American Journal of Psychiatry·Marc N PotenzaRajita Sinha
Jul 11, 2012·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Patrick D WorhunskyMarc N Potenza
Mar 15, 2013·Brain : a Journal of Neurology·Xi LuoChiang-Shan R Li
May 21, 2013·Drug and Alcohol Dependence·James J PrisciandaroKathleen T Brady
Aug 3, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M OtisDevin Mueller
Nov 10, 2013·The American Journal of Drug and Alcohol Abuse·Meredith J McHughElliot A Stein
Mar 1, 2014·Frontiers in Psychiatry·Meredith J McHughBryon Adinoff
Sep 10, 2014·Brain Research·Nathan J MarchantJennifer M Bossert
Mar 10, 2015·Biological Psychiatry·Bryon AdinoffElliot A Stein

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Citations

Sep 23, 2016·Addiction Biology·Ze WangAnna Rose Childress

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