Posterior left atrial isolation for atrial fibrillation in left ventricular diastolic impairment is associated with better arrhythmia free survival

International Journal of Cardiology
Chrishan J NalliahStuart P Thomas

Abstract

Patients with left ventricular diastolic impairment (LVDI) have higher rates of arrhythmia recurrence following atrial fibrillation (AF) ablation. Past studies have implicated the posterior left atrium (LA) in atrial arrhythmia maintenance in conditions that cause LVDI. We prospectively compared posterior LA isolation (PLAI) with wide antral isolation (WAI) in patients with LVDI having AF ablation. We conducted a sub-study of a previously published large randomized control study that compared PLAI with WAI. Two hundred and twenty consecutive consenting patients referred for catheter ablation of AF (paroxysmal 135, persistent 48, long standing persistent 37) were recruited (female 43, mean age 59 ± 10 years). Transthoracic echocardiography identified 50 (23%) patients with LVDI and preserved left ventricular systolic function (ejection fraction ≥ 50%). Cox regression analysis was utilized to identify independent predictors of atrial arrhythmia after ablation. Patients were followed for median 4.6 (inter quartile range 4.0-5.5) years. Patients with LVDI having PLAI had better arrhythmia free survival than patients randomized to conventional ablation (Log rank P=0.028). The only independent predictor of recurrence utilizing Cox re...Continue Reading

References

Jun 27, 2000·Journal of Cardiovascular Electrophysiology·P JaïsJ Clémenty
Feb 13, 2003·Circulation·Vias MarkidesNicholas S Peters
Nov 25, 2004·JAMA : the Journal of the American Medical Association·Thomas J WangEmelia J Benjamin
May 3, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·John V WylieThomas H Hauser
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Jun 6, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kurt C Roberts-ThomsonPrashanthan Sanders
Jul 4, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kurt C Roberts-ThomsonJonathan M Kalman
Jun 8, 2012·Journal of Cardiovascular Electrophysiology·Jedrzej KosiukAndreas Bollmann

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Citations

Feb 14, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichiro KumagaiTakashi Ashihara
Oct 8, 2020·Journal of Arrhythmia·Koichiro Kumagai, Hideko Toyama
Jun 4, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Akihiko NogamiUNKNOWN JCS/JHRS Joint Working Group
Aug 14, 2021·Journal of Arrhythmia·Akihiko NogamiUNKNOWN JCS/JHRS Joint Working Group

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