Posterior quadrantic dysplasia with localized hemimegalencephaly in a patient with giant congenital melanocytic nevus: First case report

The Neuroradiology Journal
Ishan KumarVineeta Gupta

Abstract

Giant congenital melanocytic nevus (GCMN) is associated with neurocutaneous melanocytosis and various other neurological complications. Its association with migrational anomalies of the brain is extremely rare. Herein, we document the first case of GCMN in a one-day-old baby associated with localized hemimegalencephaly (HME) of the brain with extensive malformation of cortical development including polymicrogyria, pachygyria and sublobar dysplasia, limited to an enlarged quadrant of the brain. HME and GCMN are considered embryological anomalies of cell migration and proliferation. We discuss the unusual magnetic resonance imaging findings along with a brief review of the literature. To the best of our knowledge, our case is the first to report the association of GCMN with localized HME.

References

May 22, 1998·Neurology·A J Barkovich, W Peacock
Jul 26, 2002·Journal of the American Academy of Dermatology·Iftikhar AhmedKenneth E Bloom
Aug 2, 2002·Journal of Child Neurology·Laura Flores-Sarnat
Jan 30, 2014·Anais Brasileiros De Dermatologia·Ana Carolina Leite VianaFlávia Vasques Bittencourt
Apr 26, 2018·Epilepsy & Behavior Case Reports·Kenchaiah RaghavendraSanjib Sinha

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Methods Mentioned

BETA
biopsy
surgical resection

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