Abstract
To investigate the effectiveness of isolated subtenon triamcinolone acetonide injection (STI) as a primary treatment in eyes with acute Vogt-Koyanagi-Harada (VKH) disease. Retrospective, observational, cross-sectional study. The data from 27 eyes in 14 patients with acute VKH treated with STI therapy were analysed retrospectively. The time course change in ocular inflammation, best corrected visual acuity (BCVA) and numbers of recurrences were examined. STI led to prompt improvement of BCVA within a week after the primary treatment. After completing therapy, patients with VKH had improved BCVA compared with baseline. In six eyes of three patients (22.2%) treated with STI, ocular inflammation was refractory, or VKH was recurrent despite the treatment. There was significant difference between groups with and without recurrences of inflammation in the frequency of headaches before treatment. In the present study, 21 eyes of 11 patients (77.8%) achieved complete resolution of VKH without recurrence after STI therapy alone. This study demonstrated that isolated STI therapy is a useful, minimally invasive, primary treatment option for patients with acute VKH without systemic disorders.
References
Jan 1, 1991·Retina·J BenizN A Rao
May 1, 1991·Archives of Ophthalmology·P E Rubsamen, J D Gass
Jan 1, 1990·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Y SasamotoH Matsuda
Dec 1, 1969·The Journal of Allergy·C E Buckley
Jan 20, 1972·The New England Journal of Medicine·A LoredoL Murillo
Sep 1, 1972·American Journal of Ophthalmology·J Herschler
Jun 1, 1969·Archives of Ophthalmology·R E Kalina
Jun 1, 1969·The British Journal of Ophthalmology·J WilliamsonW M Doig
Oct 1, 1980·Archives of Ophthalmology·H W Skalka, J T Prchal
Jul 1, 1995·American Journal of Ophthalmology·C J Helm, G N Holland
Jan 1, 1995·Survey of Ophthalmology·R S MoorthyN A Rao
Mar 1, 1996·Irish Medical Journal·N TubridyM O'Connor
Mar 23, 2001·Ocular Immunology and Inflammation·R W Read, N A Rao
May 5, 2001·American Journal of Ophthalmology·R W ReadM Usui
Jul 26, 2003·The British Journal of Ophthalmology·A A OkadaT Hida
Sep 10, 1960·JAMA : the Journal of the American Medical Association·R L BLACKJ J BUNIM
Jul 1, 1965·Archives of Ophthalmology·R W SPENCER, S Y ANDELMAN
Mar 12, 2004·American Journal of Ophthalmology·Rafael E AndradeRubens Belfort
Apr 6, 2005·American Journal of Ophthalmology·Akitaka TsujikawaYasuo Kurimoto
Nov 29, 2005·American Journal of Ophthalmology·Marc D de Smet, Narsing A Rao
Jun 9, 2006·European Journal of Ophthalmology·M KaracorluH Ozdemir
Oct 24, 2007·International Ophthalmology·Irfan PerenteOmer Faruk Yilmaz
Aug 1, 2009·Ophthalmology·Kenji IshiharaNagahisa Yoshimura
Aug 28, 2010·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Simon R J TaylorSue Lightman
Feb 5, 2014·American Journal of Ophthalmology·Yoshikatsu HosodaNagahisa Yoshimura
Citations
Apr 10, 2016·Autoimmunity Reviews·Sukhum Silpa-ArchaC Stephen Foster
Jul 13, 2017·Ocular Immunology and Inflammation·Durgasri JaisankarJyotirmay Biswas
Dec 29, 2017·Indian Journal of Ophthalmology·Muna BhendeS Ramya
Dec 11, 2017·Journal of Cataract and Refractive Surgery·Xu XuLingyun Cheng
Jan 25, 2020·European Journal of Ophthalmology·Tetsuya Muto, Shigeki Machida
Oct 9, 2021·Medicine·Po-Lin Chen, San-Ni Chen
May 25, 2021·Retina·Prithvi RamtohulK Bailey Freund