PMID: 7529224Jan 1, 1994Paper

Postextrasystolic transient contractile alternans in canine hearts

Heart and Vessels
J ArakiH Suga

Abstract

We found that postextrasystolic potentiated contractility after a spontaneous extrasystole most frequently decayed as a transient alternans over several beats in excised, cross-circulated, atrially paced canine hearts. This type of heart preparation; which we have been using consistently in mechanoenergetic studies, had normal coronary blood perfusion pressure as well as flow and mechanoenergetic performance. Spontaneous atrial and ventricular extrasystoles occurred occasionally in every heart. Arrhythmic changes in left ventricular (LV) pressure at a fixed volume reflected corresponding changes in contractility. We analyzed nearly 3,600 cases of postextrasystolic potentiation in 68 hearts; 84% decayed as transient alternans, 6% decayed exponentially, and 10% belonged to neither type. We found that a postextrasystolic compensatory pause always preceded the transient alternans after either an atrial or ventricular extrasystole at any constant atrial pacing rate (85-188 beats/min). The decay was either exponential or nonalternating when the pause did not exist after an atrial extrasystole during occasional pacing failure. Therefore, the compensatory pause after either an atrial or ventricular extrasystole seems essential for the ...Continue Reading

References

Jan 1, 1992·Heart and Vessels·Y OhgoshiH Suga
Apr 1, 1990·Physiological Reviews·H Suga
Dec 21, 1985·Journal of Theoretical Biology·D AdlerY Mahler
Jun 1, 1988·American Heart Journal·S SchaeferG J Dehmer
Sep 1, 1967·Circulation·K E CohnE W Hancock
Oct 1, 1965·American Heart Journal·W G Nayler, P G Robertson
Aug 1, 1982·Acta Physiologica Scandinavica·B Wohlfart
Dec 1, 1983·The Journal of Physiology·A J Drake-HollandB Wohlfart
Jul 1, 1984·Journal of the American College of Cardiology·O M HessH P Krayenbuehl

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Citations

Oct 30, 1999·Heart and Vessels·J MizunoH Suga
Aug 2, 2003·Clinical and Experimental Pharmacology & Physiology·Hiroyuki Suga
Nov 11, 2003·The Japanese Journal of Physiology·Juichiro ShimizuHiroyuki Suga
Jan 6, 2005·The Japanese Journal of Physiology·J MizunoH Suga
Mar 26, 2004·The Japanese Journal of Physiology·Masaki TanabeHiroyuki Suga
Feb 24, 2001·Canadian Journal of Physiology and Pharmacology·J ArakiH Suga
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S LeeH Suga
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S SuzukiH Suga
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J ShimizuH Suga

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