Postfixation of cryostat sections improves tumor definition in Mohs surgery.

The Journal of Dermatologic Surgery and Oncology
O J RustadC B Zachary

Abstract

Precise identification and localization of tumor is the key to success in Mohs micrographic surgery. In a pilot study, we demonstrated improvement in tumor definition and staining characteristics after formalin fixation of cryostat sections (postfixation) when compared with unfixed specimens. We further investigated the benefits of postfixation with a series of tissue fixatives and with varying fixation times. In all cases, postfixation was found to be beneficial. No improvement was noted by extending the postfixation time beyond 1 minute.

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Citations

Aug 1, 1990·The Journal of Dermatologic Surgery and Oncology·O J RustadC B Zachary
Mar 1, 1992·The Journal of Dermatologic Surgery and Oncology·D A Kist, C B Zachary
Nov 1, 1993·The Journal of Dermatologic Surgery and Oncology·L J MillerD C Whitaker
Jul 23, 1998·Journal of the American Academy of Dermatology·D L ShrinerR F Wagner

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