Postganglionic sympathetic neurons express endothelin

The American Journal of Physiology
D H Damon

Abstract

Endothelin (ET) is a peptide originally identified as an endothelial-derived vasoconstrictor. It is now recognized that ET is produced by and acts on many other tissues including the brain and spinal cord, where it is believed to modulate neurotransmission. The present studies demonstrate that ET is synthesized by and secreted from postganglionic sympathetic neurons. With the use of Northern analysis, ET-1 mRNA was detected in cultures of sympathetic superior cervical ganglion (SCG) neurons isolated from 3- to 5-day old rat pups. ET-1 and ET-3 peptides were also detected in cultured SCG neurons using immunohistochemistry. ET-1 (50 pg/106 cells) and ET-3 (173 pg/106 cells) were detected by radioimmunoassay of media conditioned by cultured SCG. ET-1 (77 pg/mg protein) and ET-3 (30 pg/mg protein) were also detected by radioimmunoassay of extracts of adult SCG.

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Citations

Jan 21, 2011·Physiological Reviews·Donald E KohanDavid M Pollock
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J L LiuI H Zucker
Apr 4, 2019·International Archives of Occupational and Environmental Health·Bin XiaoQingsong Chen
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D H Damon
Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·D H Damon
Jan 13, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P MilnerG Burnstock
Sep 24, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yanny E LauGregory D Fink

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