Postheparin plasma lipolytic activities in physically active and sedentary men after varying and repeated doses of intravenous heparin

Metabolism: Clinical and Experimental
P D ThompsonP N Herbert

Abstract

We sought to determine the optimal dose of heparin for evaluating the activities of lipoprotein lipase (LPLA) and hepatic triglyceride hydrolase (HTGLA) in postheparin plasma. Nine physically active and ten sedentary men (age 30 +/- 5 yr, mean +/- SD) received 30, 50, 75, and 100 IU/kg of heparin in random order during a 2-week period. Based on all the samples, the average LPLA in the athletes was 43% higher (P less than 0.001) and HTGLA was 19% lower than in the untrained subjects (NS). The greatest LPLA was obtained after a heparin dose of 75 IU/kg, but LPLA after the three highest doses were not significantly different. There was also a dose effect on HTGLA (P less than 0.001) with greatest activities following doses of 75 and 100 IU/kg. Despite these dose effects, subjects maintained their rank order for both postheparin lipase activities regardless of the heparin dose. The only exception was for LPLA in the sedentary men probably because of lower LPLA and a smaller range of values. We also examined the effect of repeated daily injections of 75 IU/kg heparin on LPLA, HTGLA, and serum lipids. Repeated heparin administration on three consecutive days produced no significant effects on the apparent lipase activities. When all ...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T M ForteA V Nichols
Sep 16, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·J K HuttunenE A Nikkilä
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T A MuslinerR S Shulman
Nov 1, 1978·The British Journal of Nutrition·A S Jackson, M L Pollock
Dec 20, 1973·Biochimica Et Biophysica Acta·S EisenbergF T Lindgren
Mar 1, 1971·The American Journal of Physiology·J C LaRosaD S Fredrickson
Dec 1, 1984·Pediatric Research·H ZaidanM Hamosh
May 1, 1984·Metabolism: Clinical and Experimental·M A KantorP D Thompson
May 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·S ValdemarssonP Nilsson-Ehle
Apr 1, 1980·Atherosclerosis·T KuusiE A Nikkilä
Jan 1, 1980·Annual Review of Biochemistry·P Nilsson-EhleM C Schotz
Sep 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M F ReardonG Steiner

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Citations

Dec 11, 2002·Biomedical Chromatography : BMC·Yukinori Eguchi
Jan 1, 1995·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·S J IversonW D Bowen
Mar 9, 2000·Transplantation·C G VinagreR C Maranhão
Jan 1, 1991·Advances in Enzyme Regulation·D M GoldbergN Bglibter
May 1, 1990·Metabolism: Clinical and Experimental·P T Williams
Aug 5, 2000·Journal of Applied Physiology·P W GrandjeanJ J Rohack
Sep 8, 1998·Journal of Applied Physiology·M A FergusonJ L Durstine
Jun 28, 2001·Medicine and Science in Sports and Exercise·P T Williams
Aug 31, 2001·The Journal of Laboratory and Clinical Medicine·B NäsströmB G Stegmayr
Nov 12, 1990·Biochimica Et Biophysica Acta·D M Goldberg, T Chajek-Shaul
Dec 1, 1992·Metabolism: Clinical and Experimental·R B TerryP D Thompson
Mar 21, 2006·Metabolism: Clinical and Experimental·Sofiya AlhassanPeter W Grandjean

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