Postictal MRI abnormalities and seizure-induced brain injury: notions to be challenged

Epilepsy & Behavior : E&B
Eugenio Grillo

Abstract

This was a bibliographic search to address the quality of evidence in clinical reports supporting the assertion that brain MRI signal abnormalities are a direct consequence of seizures. The search on PubMed was performed by applying the following inclusion criteria: a) original case reports, b) in humans, c) as single case reports or series of patients, d) of visually detected acute MRI signal abnormalities, e) attributable directly to seizures, and f) published in English. Bibliographic references of initially selected publications were reviewed for additional articles. Full texts of selected publications were read for information regarding clinical, EEG, and MRI features. Moreover, claimed evidence supporting seizure-induced excitotoxicity was assessed. The search resulted in 91 publications corresponding to 413 cases. There was a wide range of clinical features and EEG and MRI abnormalities. Premorbid or comorbid conditions were present in many cases, and some of them are potential causes of MRI changes. Claimed evidence for MRI signal abnormalities as a direct consequence of ictal activity was mostly based on the similarity with previous reports, animal models, reversibility, congruent EEG, MRI changes not respecting vascul...Continue Reading

References

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Citations

May 14, 2016·Neurocritical Care·Gregory Kapinos, Jan Claassen
May 21, 2019·Journal of Investigative Medicine High Impact Case Reports·Alexander B RamosEdward C Mader
Jan 5, 2017·Movement Disorders Clinical Practice·Masayuki SasakiShinichi Hirose
Nov 11, 2019·Seizure : the Journal of the British Epilepsy Association·Donald P CraigRhys H Thomas
Nov 19, 2021·Journal of the American Veterinary Medical Association·Christian MaesoPatrícia Montoliu

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