PMID: 6112279Mar 1, 1981Paper

Postinfection control in T4 bacteriophage infection: inhibition of the rep function

Journal of Virology
K Ebisuzaki, S B Jellie

Abstract

We suggest that the general mechanism by which T4 phage turns off host macromolecular synthesis involves specific phage proteins which react with key components in the synthetic pathway. Support for this mechanism exists for the inhibition of host RNA synthesis. Here we note that the host rep function was inhibited after T4 phage infection. Since rep functions are known to be involved in host DNA replication, inhibition of rep might alter the course of host DNA replication.

References

Jan 1, 1975·Journal of Virology·M T Behme, K Ebisuzaki
May 2, 1977·European Journal of Biochemistry·R M Purkey, K Ebisuzaki
Jan 1, 1979·Cold Spring Harbor Symposia on Quantitative Biology·J RosamondS Linn
Jun 1, 1979·Canadian Journal of Biochemistry·S TakahashiD T Denhardt
Jun 1, 1979·Microbiological Reviews·J F Koerner, D P Snustad
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R MailhammerG Zubay
Jan 1, 1973·Annual Review of Genetics·A J Clark
Oct 9, 1970·Biochemical and Biophysical Research Communications·N DebreceniK Ebisuzaki
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R P Lieberman, M Oishi
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A Stevens
Nov 1, 1974·Journal of Bacteriology·H E Lane, D T Denhardt
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P J Goldmark, S Linn
Mar 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·D T DenhardtA Hathaway

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Citations

Jan 1, 2012·F1000Research·Timothée PoisotMichael E Hochberg

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