Postinhibitory rebound during locomotor-like activity in neonatal rat motoneurons in vitro

Journal of Neurophysiology
S Bertrand, J R Cazalets

Abstract

The aim of this study was to establish how a membrane property contributes to the neuronal discharge during ongoing behavior. We therefore studied the role of the postinhibitory rebound (PIR) in the bursting discharge of lumbar motoneurons intracellularly recorded in newborn rat in vitro brain stem/spinal cord preparation. The PIR is a transient depolarization that occurs after a hyperpolarization. We first investigated how it was expressed during experimentally induced hyperpolarizations. Its amplitude increased with the inhibition and was voltage dependent. The Ca2+ channel blockers Mn2+ and Co2+ partly suppressed the PIR in a few of the motoneurons tested. When hyperpolarized, the motoneurons exhibited a sag that was associated with the PIR. Adding caesium to the bath abolished both sag and rebound, which suggested that the PIR in the lumbar motoneurons was mainly due to the activation of the inward rectifying current IQ. In the second part, we studied the physiological involvement of PIR during fictive locomotion induced by bath application of N-methyl-D-L-aspartate and serotonin. We established that experimentally induced PIR could initiate or modulate the bursting discharge of motoneurons during fictive locomotion. We the...Continue Reading

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Citations

Mar 3, 1999·The European Journal of Neuroscience·S Bertrand, J R Cazalets
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Apr 20, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James D AngstadtSarah M Levasseur
Oct 16, 2009·Journal of Neurophysiology·Arnaud Pambo-PamboJean-Patrick Gueritaud
Oct 14, 2011·Journal of Neurophysiology·Tatiana M AndersonMark A Masino
Jul 18, 2012·PloS One·Tomonori TakazawaAmy B Macdermott
May 11, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Duane C Button, Jayne M Kalmar
Nov 15, 2002·The European Journal of Neuroscience·S Bertrand, Jean-René Cazalets
Apr 12, 2000·Journal of Neurophysiology·M GorassiniH Hultborn
Jun 4, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James D Angstadt, Amanda M Simone
May 13, 2017·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James D AngstadtAlexander J Goncalves
Feb 20, 2020·Journal of Neurophysiology·Morgan M HighlanderSherif M Elbasiouny
Dec 22, 1999·Progress in Biophysics and Molecular Biology·R E Russo, J Hounsgaard
Jun 15, 2021·Respiratory Physiology & Neurobiology·Edward J ZuperkuAstrid G Stucke
Aug 23, 2005·Brain Research. Brain Research Reviews·Livia CarrascalPedro A Nunez-Abades
Aug 11, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Thomas J PirtleRichard A Satterlie

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