PMID: 6760664Nov 1, 1982

Postinitial remission in diabetic children--an analysis of 178 cases

Acta paediatrica Scandinavica
Mikael KnipH K Akerblom

Abstract

We studied 178 diabetic children and adolescents diagnosed during the period 1962-79 to find out the occurrence and duration of the postinitial remission, factors favoring a remission and the prognostic value of the remission. A postinitial remission occurred in 113 children (64%) being complete in only three boys (2%). The duration ranged from one month to 4.8 years, the mean being 8.4 months. The boys had a remission more often and of longer duration than the girls. The duration of diabetes was longer in the children without remission. The children with remission had lower blood glucose, milder hyperketonemia and ketonuria, higher pH and PCO2 at onset than those without remission. Hemoglobin A1 (HbA1) during 1979 were lower in the children with a positive remission history. The children with a remission lasting more than one year had a subsequently higher glucosuria index, lower HbA1 and higher C-peptide when compared to those without remission or to those with a short remission. The remission frequency increased from 1962 to 1979. Male sex and mild metabolic derangement at onset favor a postinitial remission, which results in a persisting residual beta-cell function and better metabolic control beyond the remission.

References

Jul 1, 1982·Acta diabetologica latina·Mikael KnipH K Akerblom
Nov 26, 2002·Journal of Hepatology·Jean François DufourJürg Reichen
Jan 19, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S A BrodW J Riley
Apr 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·C Lévy-MarchalP Czernichow
Apr 1, 1989·Archives of Disease in Childhood·D I Johnston
Mar 23, 1999·Archives of Disease in Childhood·B J MuhammadJ L Botha
Apr 1, 1986·European Journal of Pediatrics·C E de BeaufortR van Strik
Dec 1, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·D DevendraT J Wilkin
Jul 10, 2008·Diabetes/metabolism Research and Reviews·Maria Nordwall, Johnny Ludvigsson
Jun 7, 2005·Diabetes Research and Clinical Practice·P PozzilliIMDIAB group
Nov 1, 1988·Acta paediatrica Scandinavica·G DahlquistS Wall
Jan 1, 1985·Acta Paediatrica Scandinavica. Supplement·L Blom, G Dahlquist
Jun 1, 1987·Acta Paediatrica Japonica; Overseas Edition·B Weber, M Hasala
Mar 19, 1999·Journal of Internal Medicine·A SchölinE Björk
Jul 9, 2016·Expert Review of Molecular Diagnostics·Johnny Ludvigsson
Feb 1, 1993·Diabetes Research and Clinical Practice·M T YilmazF Sipahioğlu
Jun 5, 2018·Pediatric Diabetes·Maaret TurtinenFinnish Pediatric Diabetes Register
Oct 14, 2005·Diabetes/metabolism Research and Reviews·Beate KargesWolfram Karges
Sep 8, 2017·Pediatric Diabetes·Julia von SchnurbeinCeline Vetter
Mar 17, 1988·The New England Journal of Medicine·P F BougneresJ L Chaussain

Citations

Jan 1, 1977·Acta Paediatrica Scandinavica. Supplement·H K Akerblom
Jan 1, 1977·Acta Paediatrica Scandinavica. Supplement·O O Andersen, J Egeberg
Jan 1, 1978·Diabetes·J Ludvigsson, L G Heding
Mar 1, 1978·Diabetologia·S G Welch, B J Boucher
Dec 1, 1976·Diabetologia·Johnny Ludvigsson, L G Heding
Mar 25, 1967·British Medical Journal·T A WelbornT R Fraser
Feb 1, 1980·Acta Endocrinologica·S MadsbadI Transbøl

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