Postischaemic interrelations between energy metabolism and functional recovery of protected canine kidneys

European Journal of Clinical Investigation
G KehrerH J Bretschneider

Abstract

Following renal ischaemia under effective protection glomerular filtration starts at a time when renal high-energy phosphates are resynthesized. The present investigation was carried out to examine the interdependence of the two processes. Therefore, canine kidneys were protected with sodium poor and nominally Ca2+ free buffered solutions. After different times of ischaemia and reperfusion the glomerular filtration rates (GFR) were determined and afterwards tissue specimens were excised for the determination of high-energy phosphates. Both the GFR and the renal energy content were higher with shorter ischaemia periods or longer reperfusion. As a rule there was a correlation between GFR and ATP, both probably mainly signifying the degree of preservation of proximal nephron sites, as the interrelation between the GFR and the renal SAN (ATP + ADP + AMP) content also signifies. However, with the addition of aspartate to the protective solution it could be demonstrated that the GFR also can rise without a concomitant increase of ATP. Under certain conditions an increase of GFR can even be associated with a lowering of the renal ATP content.

References

Mar 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·M R Buhl
Mar 1, 1986·Kidney International·L Fine
Jan 1, 1989·Urological Research·G KehrerH J Bretschneider
Jan 1, 1986·Pflügers Archiv : European journal of physiology·G SzénásiL Takács
Jan 1, 1986·Annual Review of Physiology·S P Soltoff
Sep 15, 1988·Klinische Wochenschrift·H J BretschneiderG Kehrer
Jan 1, 1988·Annual Review of Medicine·J V Bonventre
Oct 1, 1984·The Journal of General Physiology·S P Soltoff, L J Mandel
Jan 1, 1983·Annual Review of Physiology·E E Windhager, A Taylor
Sep 1, 1982·The American Journal of Physiology·S R FindlayC R Scheid

❮ Previous
Next ❯

Citations

Jan 1, 1990·Langenbecks Archiv für Chirurgie·G GubernatisH J Bretschneider
Feb 15, 1990·Klinische Wochenschrift·G Kehrer, H J Bretschneider
May 2, 1989·Klinische Wochenschrift·G KehrerH J Bretschneider
Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·G KehrerH J Bretschneider
Mar 1, 1991·Kidney International·J M Weinberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.