Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils

European Journal of Pharmacology
D K von LubitzK A Jacobson

Abstract

Although adenosine receptor-based treatment of cerebral ischemia and other neurodegenerative disorders has been frequently advocated, cardiovascular side effects and an uncertain therapeutic time window of such treatment have constituted major obstacles to clinical implementation. Therefore, we have investigated the neuroprotective effects of the adenosine A1 receptor agonist adenosine amine congener (ADAC) injected after either 5 or 10 min ischemia at 100 micrograms/kg. When the drug was administered at either 6 or 12 h following 5 min forebrain ischemia, all animals were still alive on the 14th day after the occlusion. In both ADAC treated groups neuronal survival was approximately 85% vs. 50% in controls. Administration of a single dose of ADAC at times 15 min to 12 h after 10 min ischemia resulted in a significant improvement of survival in animals injected either at 15 or 30 min, or at 1, 2, or 3 h after the insult. In all 10 min ischemia groups, administration of ADAC resulted in a significant protection of neuronal morphology and preservation of microtubule associated protein 2 (MAP-2). However, postischemic Morris' water maze tests revealed full preservation of spatial memory and learning ability in animals injected at ...Continue Reading

References

Aug 14, 1992·European Journal of Pharmacology·D K Von LubitzP Skolnick
Jan 1, 1990·Journal of Molecular Neuroscience : MN·D K von Lubitz, P J Marangos
Aug 1, 1989·Stroke; a Journal of Cerebral Circulation·R BustoM D Ginsberg
Apr 1, 1988·Trends in Pharmacological Sciences·B B Fredholm, T V Dunwiddie
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jan 1, 1981·Progress in Neurobiology·J W Phillis, P H Wu
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö
Jun 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KågströmB K Siesjö
Sep 15, 1995·Annals of the New York Academy of Sciences·D K von LubitzK A Jacobson
Sep 22, 1994·European Journal of Pharmacology·D K Von LubitzK A Jacobson
Jan 1, 1993·Molecular and Chemical Neuropathology·P Andiné
Mar 1, 1996·Trends in Pharmacological Sciences·K A JacobsonB B Fredholm
Jan 1, 1989·Neurochemistry International·M Williams

❮ Previous
Next ❯

Citations

Oct 1, 1997·Drug Development Research·John W DalyKenneth A Jacobson
Sep 2, 2010·Purinergic Signalling·Srdjan M VlajkovicPeter R Thorne
Aug 31, 2001·European Journal of Pharmacology·U AdénB B Fredholm
Mar 17, 1999·European Journal of Pharmacology·D K Von LubitzK A Jacobson
Sep 30, 2000·Brain Research. Brain Research Reviews·A de MendonçaJ A Ribeiro
May 26, 1999·Progress in Neurobiology·F Block
Aug 7, 2012·Acta Pharmacologica Sinica·Nicholas L WeilingerRoger J Thompson
Mar 7, 2006·Nature Reviews. Drug Discovery·Kenneth A Jacobson, Zhan-Guo Gao
Oct 25, 2008·Journal of Nanobiotechnology·Athena M KlutzKenneth A Jacobson
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Kenneth D BrombergJohn Cijiang He
Nov 20, 2015·Neuropharmacology·Felicita PedataAnna Maria Pugliese
Aug 2, 2005·Neuroscience Letters·Dar-Ming LaiJuei-Tang Cheng
Sep 23, 2014·BioMed Research International·Srdjan M VlajkovicPeter R Thorne
Feb 15, 2017·BioMed Research International·Hao ChangSrdjan M Vlajkovic
Sep 13, 2011·Progress in Neurobiology·Geoffrey BurnstockPeter Illes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.