PMID: 9535112Apr 16, 1998Paper

Postischemic hyperthermia increases expression of hsp72 mRNA after brief ischemia in the gerbil

Neuroscience Letters
S Suga, Thaddeus S Nowak

Abstract

Brain temperature during ischemia critically determines insult severity, and temperature changes during recirculation may also affect subsequent injury. We have examined the impact of postischemic temperature on induction of the 70 kDa stress protein, hsp72, after brief ischemia in the gerbil. Animals were subjected to 2 min ischemia after which they were maintained under continuous halothane anesthesia during 3 h recirculation, and were either kept normothermic or subjected to hyperthermia comparable to that which occurs spontaneously in gerbils released from anesthesia immediately after the occlusion. Quantitative in situ hybridization showed striking dependence of hsp72 induction on postischemic hyperthermia. This result establishes that delayed temperature-sensitive signals mediate this injury-associated transcriptional response, and demonstrates that postischemic temperature must be carefully monitored in studies of gene expression and induced tolerance employing brief ischemic insults.

References

Feb 11, 1990·Journal of Neurochemistry·T S NowakM J Schlesinger
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Citations

Dec 23, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hiroshi Abe, Thaddeus S Nowak
May 7, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takatoshi Sorimachi, Thaddeus S Nowak
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S D HicksC W Callaway
Oct 16, 2004·The Korean Journal of Internal Medicine·Dong-Jin OhEung-Tack Kang

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