Postlaminectomy adhesion of the cauda equina. Changes of postoperative vascular permeability of the equina in rats

Spine
M NakanoH Tsuji

Abstract

The authors evaluated the vascular permeability changes of the cauda equina after lumbar laminectomy in rats. To clarify the early vascular responses in postlaminectomy adhesive arachnoiditis. Laminectomy-induced cauda equina adhesion has been visualized by postoperative serial magnetic resonance imaging in humans. In laminectomized rats, fibrinous exudation was apparent among the adhered cauda equina. To date, there has been no report of substantial changes in vascular permeability in the cauda equina after lumbar laminectomy. Wistar rats laminectomized from L5-L6 were used for four studies; 1) Evans blue albumin tracer study; 2) horseradish peroxidase tracer study; 3) lanthanum tracer study; and 4) fluoroscein isothiocyanate-dextran (molecular weights: 20K, 70K, and 150K) tracer study. Untreated rats were used as controls. 1) In the laminectomized (L5-L6) area, the cauda equina tended to conglomerate from 3 hours after surgery; this was relatively resolved by 6 weeks. Extravascular leakage of Evans blue albumin in the cauda equina appeared at 3 hours after surgery and reached a plateau at 24 hours; it mostly disappeared by 6 weeks. At 24 hours after surgery, the extent of Evans blue albumin extravasation was seen in one or mo...Continue Reading

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Citations

Mar 3, 2011·Journal of Neurotrauma·Samuel J MackenzieBlair Calancie
Dec 14, 2011·Asian Spine Journal·Toshinori SakaiNatsuo Yasui
Aug 5, 2004·The Journal of Bone and Joint Surgery. American Volume·Yoshiharu KawaguchiTomoatsu Kimura

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