PMID: 7931875Oct 1, 1994Paper

Postlicensure effectiveness of the Haemophilus influenzae type b polysaccharide-Neisseria meningitidis outer-membrane protein complex conjugate vaccine among Navajo children

The Journal of Pediatrics
L H HarrisonM Santosham


The incidence of invasive Haemophilus influenzae type b (Hib) infection was decreased significantly among Navajo children since the licensure of Hib conjugate vaccines, even though two lots of Hib (polyribosylribitol phosphate)-meningococcal B outer-membrane protein conjugate vaccine (PRP-OMP) widely used among the Navajo were later found to be of low immunogenicity. We measured the effectiveness of all Hib conjugate vaccines combined, PRP-OMP alone, and the PRP-OMP lots with lower-than-expected immunogenicity among Navajo infants and children. This was a matched case-control study using active, laboratory-based surveillance for the ascertainment of Navajo children 2 1/2 to 59 months of age with invasive Hib infection; 45 patients with infection and 180 control subjects were enrolled. The effectiveness of one, two, and three doses, respectively, of all Hib conjugate vaccines combined was 96% (95% confidence interval (CI) 65%, 99%), 99% (95% CI, 69%, 100%), and 99% (95% CI - 57%, 100%). The effectiveness of one or more doses of PRP-OMP was 95% (95% CI, 66%, 99%). The effectiveness of a single dose of the lots of lower-than-expected immunogenicity was 89% (95% CI, -8%, 99%). The Hib conjugate vaccine coverage increased from 49% d...Continue Reading


Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L H Harrison
Dec 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N A Halsey
Dec 16, 1998·Australian and New Zealand Journal of Public Health·J N HannaD E Andrews
Jan 19, 2006·Clinical Microbiology Reviews·Lee H Harrison
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Jul 5, 2005·Expert Opinion on Investigational Drugs·R K Sood, A Fattom
Dec 23, 1999·The Pediatric Infectious Disease Journal·D A ClementsE B Walter
Oct 3, 2001·Annals of Tropical Paediatrics·T TauberM Berkovitch

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