PMID: 8584366Nov 1, 1995Paper

Postlicensure surveillance for Haemophilus influenzae type b invasive disease after use of Haemophilus influenzae type b oligosaccharide CRM197 conjugate vaccine in a large defined United States population: a four-year eight-month follow-up

The Pediatric Infectious Disease Journal
H Shinefield, S Black

Abstract

Haemophilus influenzae type b (Hib) oligosaccharide CRM197 (HbOC-HibTITER, Lederle-Praxis) conjugate vaccine was approved for use in infants in October, 1990, as a result of an evaluation of 61,080 infants in whom the vaccine was found to be safe and effective. This report details a 4-year 8-month period of surveillance after the licensure of this vaccine in the large defined United States population from which these children were drawn. The population analyzed consisted of approximately 240,000 children from 0 through 8 years of age in a total health plan population of 2,500.000. During this period 16 cases of invasive Hib disease were identified. Nine had not received any type of Hib vaccine, 2 had received the unconjugated polysaccharide Hib vaccine and 4 had received the HbOC vaccine. Of this latter group one toddler had received a single dose of the vaccine at 18 months of age < 24 hours before becoming ill, two 7-month-old infants had received a single dose of the vaccine at 2 or 3 months of age and one 3-year 4-month-old child had received three doses of HbOC vaccine as an infant but had never received the recommended booster dose. The 16th case occurred on July 10, 1994, in a 7- year-old child who at 18 months of age ha...Continue Reading

Citations

Jul 4, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mira KojouharovaUNKNOWN Bulgarian Hib Study Team
Mar 20, 2003·The Journal of Infection·M C ZacharisenJ Edwards
Feb 20, 1998·The Pediatric Infectious Disease Journal·S UsenB Greenwood
Jul 19, 2011·Trends in Microbiology·Johanna M C JefferiesAlex R Kraaijeveld
Sep 7, 2016·BMC Infectious Diseases·Han Wool KimMoon H Nahm
Mar 3, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anna Söderlund-StrandJoakim Dillner

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