Postlicensure surveillance of human papillomavirus vaccine using the Vaccine Adverse Event Reporting System, 2006-2017

Perspectives in Clinical Research
Reddy NehaEswaran Maheswari

Abstract

The United States Food and Drug Administration (FDA) has licensed three HPV (Human papilloma virus) vaccines. The centers for disease control and prevention (CDC) and advisory committee on immunization practices (ACIP) recommends routine HPV vaccination at age 11 or 12 years. This study aimed to summarize and characterize adverse events following HPV vaccination reported to VAERS database from July 2006 to May 2017. A systematic data mining was performed in the VAERS database for reports associated with HPV vaccine. Clinically relevant Vaccine Event Combinations (VEC) were identified in the VAERS database following HPV vaccination. A VEC was considered for analysis only if a minimum of hundred reports were present in database for the given Adverse Event (AE). The data mining algorithm used in this study was reporting odds ratio. A value of ROR-1.96SE >1 was considered as positive signal. VAERS received 49444 reports after receipt of HPV vaccine during the study period. Out of 49444, 2307 unique reactions were identified. A total of 177 death reports and 3526 non death serious reactions were reported to VAERS. ROR showed positive signals for abdominal pain, syncope, dizziness, convulsion, abortion spontaneous, alopecia, amenorrh...Continue Reading

References

Sep 20, 1995·Journal of the National Cancer Institute·G Y HoS Romney
May 1, 1994·Vaccine·R T ChenS G Wassilak
May 5, 1997·The American Journal of Medicine·L Koutsky
Jan 22, 2003·Journal of General Internal Medicine·Syed Rizwanuddin Ahmad
Jun 15, 2005·Pharmacoepidemiology and Drug Safety·David BanksRobert Ball
Nov 29, 2005·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Anna-Barbara Moscicki
Jul 8, 2008·Vaccine·Ph DebeerR Devlieger
Sep 3, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Julia M L BrothertonUNKNOWN New South Wales Health HPV Adverse Events Panel
Apr 28, 2009·Infectious Disease Clinics of North America·Alexandros P GrammatikosMatthew E Falagas
Aug 20, 2009·JAMA : the Journal of the American Medical Association·Barbara A SladeJohn Iskander
Jun 15, 2012·The New England Journal of Medicine·Nobuhiro Yuki, Hans-Peter Hartung
Jul 26, 2015·Vaccine·Tom T ShimabukuroFrank DeStefano

❮ Previous
Next ❯

Software Mentioned

VAERS

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.