Postmastectomy radiation for N2/N3 breast cancer: factors associated with low compliance rate

Journal of the American College of Surgeons
Quyen D ChuBeth Townsend

Abstract

The National Comprehensive Cancer Network and American Society of Clinical Oncology guidelines recommend postmastectomy radiation therapy (PMRT) for women with N2/N3 breast cancer. We examined the compliance rate of PMRT using the National Cancer Data Base and determined what factors are associated with low compliance rate with PMRT. The National Cancer Data Base, comprising 2,720,368 breast cancer cases diagnosed between 1998 and 2011, was evaluated. From this database, 56,990 women with N2/N3 diseases were evaluated. Statistics used include chi-square test, 2-sample t-test or Wilcoxon rank-sum test, and multivariate analysis. Mean age of the patients was 58 years and median follow-up was 61 months. The majority of patients were from a comprehensive community cancer programs (59%), were Caucasian (81%), had health insurance (96%), resided in urban communities (98%), and had no comorbidities (83%). Approximately 82% received chemotherapy, but only 65% had PMRT. Factors associated with PMRT are tumor grade (p = 0.03), regional lymph node surgery (p = 0.03), readmission within 30 days of surgical discharge (p = 0.03), receipt of chemotherapy (p < 0.01) and hormonal therapy (p < 0.01), and 30-day mortality (p < 0.01). Socioeconomi...Continue Reading

References

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Citations

Mar 24, 2016·Annals of Surgical Oncology·Adena S ScheerDavid R McCready
May 23, 2016·International Journal of Radiation Oncology, Biology, Physics·Catherine Loveland-JonesGildy Babiera
Jun 15, 2018·Expert Review of Anticancer Therapy·Apar GuptaBruce G Haffty

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