Postmeal exercise blunts postprandial glucose excursions in people on metformin monotherapy

Journal of Applied Physiology
Melissa L EricksonNathan T Jenkins

Abstract

Metformin is used clinically to reduce fasting glucose with minimal effects on postprandial glucose. Postmeal exercise reduces postprandial glucose and may offer additional glucose-lowering benefit beyond that of metformin alone, yet controversy exists surrounding exercise and metformin interactions. It is currently unknown how postmeal exercise and metformin monotherapy in combination will affect postprandial glucose. Thus, we examined the independent and combined effects of postmeal exercise and metformin monotherapy on postprandial glucose. A randomized crossover design was used to assess the influence of postmeal exercise on postprandial glucose excursions in 10 people treated with metformin monotherapy (57 ± 10 yr, HbA1C = 6.3 ± 0.6%). Each participant completed the following four conditions: sedentary and postmeal exercise (5 × 10-min bouts of treadmill walking at 60% V̇o2max) with metformin and sedentary and postmeal exercise without metformin. Peak postprandial glucose within a 2-h time window and 2-h total area under the curve was assessed after a standardized breakfast meal, using continuous glucose monitoring. Postmeal exercise significantly blunted 2-h peak (P = 0.001) and 2-h area under the curve (P = 0.006), with ...Continue Reading

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Citations

May 23, 2018·Journal of Diabetes Research·Tao HuangSulin Cheng
Aug 28, 2020·Frontiers in Endocrinology·Steven K Malin, Nathan R Stewart
Oct 5, 2017·Frontiers in Endocrinology·Melissa L EricksonKevin K McCully
Mar 15, 2019·Nature Reviews. Drug Discovery·Gregory R Steinberg, David Carling
Apr 16, 2021·Endocrinology, Diabetes & Metabolism·Diana AbdalhkJennifer L Kuk
Jul 24, 2020·Clinical Diabetes : a Publication of the American Diabetes Association·Elsamma Chacko, Christine Signore

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