PMID: 2107106Apr 1, 1990Paper

Postmenopausal androgen secreting ovarian tumour: pathophysiological implications; a case report

European Journal of Obstetrics, Gynecology, and Reproductive Biology
A PérezA de Leiva

Abstract

Hyperandrogenism in women is usually accompanied by a disruption of the hypothalamic-pituitary-ovarian axis; however, the precise effect of chronically elevated androgens on this axis is poorly understood. We report a postmenopausal woman with a virilizing ovarian tumour in whom the effects of chronic testosterone secretion on the hypothalamic-pituitary axis was investigated. A 56-year-old woman was evaluated for hirsutism and hyperandrogenism of recent onset. Peripheral serum testosterone was high (19.4 nmol/l), while gonadotropins were below normal for a postmenopausal woman, FSH (19.7 IU/l) being higher than LH (10.3 IU/l). Four LH and 1 FSH pulse were detected over 4 h. A left intraovarian testosterone secreting tumour, shown by catheterization of the ovarian veins and containing imperfect crystalloids of Reinke, was excised. Postoperatively, peripheral testosterone became undetectable, while gonadotropins rose to normal postmenopausal values. This patient's LH/FSH ratio was less than 1, in contrast with other situations of chronic hyperandrogenism. This could be explained by the concomitant hypoestrogenic state, and/or the theoretical absence of inhibin. The interest of this case resides in that it constitutes an appropria...Continue Reading

References

Sep 1, 1979·The Journal of Clinical Endocrinology and Metabolism·Z RosenwaksA C Wentz
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·D T BairdP F Van Look
May 1, 1986·Endocrine Reviews·D A Freeman
Jul 1, 1986·The Journal of Clinical Endocrinology and Metabolism·A Dunaif
Dec 1, 1986·American Journal of Obstetrics and Gynecology·P SerafiniR A Lobo
May 1, 1986·Clinical Endocrinology·P DewisD C Anderson
Dec 1, 1987·The Journal of Clinical Endocrinology and Metabolism·M VermeshR A Lobo
Oct 11, 1973·The New England Journal of Medicine·E E WerkL Kalejs
Jul 1, 1984·The Journal of Clinical Endocrinology and Metabolism·J D VeldhuisM L Johnson
May 1, 1957·American Journal of Obstetrics and Gynecology·W C KEETTELF J STODDARD
Nov 1, 1961·The Journal of Clinical Endocrinology and Metabolism·D FERRIMAN, J D GALLWEY

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Citations

Sep 1, 1996·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·B S Verkauf, E Ruffolo

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