Postmenopausal estradiol-progestagen therapy and risk for uterine cervical cancer

International Journal of Cancer. Journal International Du Cancer
Susanna JaakkolaO Ylikorkala

Abstract

The aim of this study was to evaluate the association of postmenopausal estradiol-progestagen therapy (EPT) with the risk for precancerous lesions, squamous cell carcinoma and adenocarcinoma of the uterine cervix. All Finnish women who had used EPT in 1994-2008 for at least 6 months (n = 243,857) at the age of 50 years or more were identified from the national Medical Reimbursement Registry and linked to the Finnish Cancer Registry. The incidence of cervical precancerous or cancerous lesions among EPT users was compared to that in the background population. There were 210 EPT users with squamous lesions (178 with precancerous and 32 with cancer) and 79 EPT users with glandular lesions (14 precancerous and 65 adenocarcinomas). The ever use of EPT did not associate with the incidence of precancerous lesions, but the risk for squamous cell carcinoma decreased (standardized incidence ratio 0.41; 95% confidence interval 0.28-0.58) and that for adenocarcinoma increased (1.31; 1.01-1.67). After the use of EPT for 5 years, the risk for squamous cell carcinoma decreased (0.34; 0.16-0.65), and the risk for adenocarcinomas increased (1.83; 1.24-2.59). The prolonged use of EPT is associated with the occurrence of cervical malignancies. If ...Continue Reading

References

Aug 1, 1987·Cancer·R E HunterP Keough
Jun 1, 1994·Scandinavian Journal of Social Medicine·I KeskimäkiJ Teperi
Jun 1, 1993·Journal of Epidemiology and Community Health·J Teperi
Jul 12, 1997·BMJ : British Medical Journal·F ParazziniG Bolis
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Diane SolomonUNKNOWN Bethesda 2001 Workshop
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Freddie BrayD Max Parkin
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Freddie BrayElisabete Weiderpass
Dec 19, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anthony S GunnellSamuli Ripatti
Dec 24, 2008·Obstetrics and Gynecology·Heli LyytinenOlavi Ylikorkala
May 19, 2009·International Journal of Cancer. Journal International Du Cancer·Peter SasieniJack Cuzick
Nov 26, 2009·Obstetrics and Gynecology·Susanna JaakkolaOlavi Ylikorkala
Dec 17, 2009·Acta Oncologica·Eero PukkalaMatti Hakama
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Lisen Arnheim DahlströmPär Sparén
Feb 1, 2011·International Journal of Cancer. Journal International Du Cancer·Susanna JaakkolaEero Pukkala
Feb 2, 2011·Journal of the National Cancer Institute·Mark SchiffmanPhilip E Castle

❮ Previous
Next ❯

Citations

Feb 14, 2016·Climacteric : the Journal of the International Menopause Society·R J BaberUNKNOWN IMS Writing Group
Apr 10, 2015·Journal of Lower Genital Tract Disease·Grace FrielKirsten B Moysich
Jun 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Agata TomaszewskaPaweł Piotr Jagodziński
Nov 19, 2014·Menopause : the Journal of the North American Menopause Society·Asa Hallqvist EverhovKarin E Smedby
Sep 30, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·E L MossH McDermott
Nov 26, 2020·Climacteric : the Journal of the International Menopause Society·V VargiuP Villa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Journal of Occupational and Environmental Medicine
Anssi AuvinenTapio Rytömaa
Journal of Occupational and Environmental Medicine
Madar TalibovE Pukkala
Annals of Oncology : Official Journal of the European Society for Medical Oncology
B Pérez-GómezCervical Cancer Working Group
International Journal of Cancer. Journal International Du Cancer
Lisen Arnheim DahlströmP Sparen
© 2022 Meta ULC. All rights reserved