Postmenopausal hormone therapy and the risk of rheumatoid arthritis: results from the Swedish EIRA population-based case-control study

European Journal of Epidemiology
Cecilia OrellanaCamilla Bengtsson

Abstract

To study the association between postmenopausal hormone therapy (PMH) use and the risk of rheumatoid arthritis (RA) stratifying the cases by the presence/absence of antibodies against citrullinated peptides (ACPA). A subset of the Epidemiological Investigation of RA (EIRA), a population-based case-control study, comprising postmenopausal women aged 50-70 living in Sweden, between 2006 and 2011 was analysed (523 cases and 1057 controls). All participants answered an extensive questionnaire, including questions regarding PMH use and potential confounders (education, smoking, BMI, oral contraceptives, reproductive factors). We calculated odds ratios (OR) of developing ACPA-positive/-negative RA, with 95% confidence intervals (CI) and adjusted for age, residential area and smoking. Current users of PMH had a decreased risk of ACPA-positive RA compared with never users (OR 0.6, 95% CI 0.3-0.9). The decreased risk was observed mainly in the age-group 50-59 years (OR 0.3, 95% CI 0.1-0.8) but not in the age-group 60-70 years (OR 0.8, 95% CI 0.4-1.4). Among current users of a combined therapy (estrogen plus progestogens) an OR of 0.3 (95% CI 0.1-0.7) of ACPA-positive RA was observed, while no significant association was found among wome...Continue Reading

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Citations

Oct 1, 2016·Rheumatology·Deshiré Alpízar-RodríguezAxel Finckh
Apr 10, 2017·Rheumatic Diseases Clinics of North America·Mitali Talsania, Robert Hal Scofield
Oct 25, 2017·European Journal of Epidemiology·M Arfan IkramAlbert Hofman
Aug 19, 2017·Annals of the Rheumatic Diseases·Cecilia OrellanaCamilla Bengtsson
Feb 28, 2017·JCI Insight·Altan ErcanPeter A Nigrovic
Oct 1, 2020·Journal of Clinical Medicine·Carine SalliotRaphaèle Seror
Apr 30, 2017·Seminars in Immunopathology·Deshiré Alpízar-Rodríguez, Axel Finckh
May 22, 2019·Frontiers in Endocrinology·Maunil K Desai, Roberta Diaz Brinton
Oct 4, 2020·Nature Reviews. Rheumatology·Maurizio Cutolo, Rainer H Straub
Dec 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Debolina ChakrabortySagarika Biswas
Dec 10, 2017·Best Practice & Research. Clinical Rheumatology·Kevin D DeaneV Michael Holers

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Methods Mentioned

BETA
ELISA
hormone replacement therapy

Software Mentioned

SAS )

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