Postmenopausal obesity as a breast cancer risk factor according to estrogen and progesterone receptor status (Japan)

Cancer Letters
K Y YooS Miura

Abstract

There have been inconsistent results on the association of postmenopausal obesity with breast cancer risk according to the estrogen (ER) and/or progesterone receptor (PR) status in the breast tissue, and this requires further evaluation. This study was designed to assess whether postmenopausal obesity differs according to receptor status. Information on risk factors was obtained from 1154 breast cancer cases and 21714 controls at Aichi Cancer Center Hospital, Nagoya, Japan between 1988 and 1992. The receptor status was known for 40% of cases. Obese postmenopausal women showed an increased risk of breast cancer (odds ratio (OR) for 5 kg of current weight=1.17, 95% confidence interval (CI)=1.10-1.25; OR for 1 kg/m(2) of body mass index (BMI)=1.07, 95% CI=1.04-1.10). The elevated OR was strongest for ER-positive, as well as with PR-positive, breast cancer among postmenopausal women who had a high BMI. The risk did not differ significantly according to ER status. However, obesity indices among postmenopausal women differed with borderline significance according to PR status. These results are consistent with the hypothesis that there is a gradient of risk for postmenopausal obesity according to hormonal receptor status, at least fo...Continue Reading

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Citations

Jul 15, 2009·Breast Cancer Research and Treatment·Carole DegliseHelena Marieke Verkooijen
Nov 10, 2013·PloS One·Boyoung ParkSue K Park
Aug 11, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yoichiro KakugawaTsuneaki Fujiya
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Jan 10, 2004·Integrative Cancer Therapies·D Barry Boyd
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Apr 29, 2006·International Journal of Cancer. Journal International Du Cancer·Reiko SuzukiAlicja Wolk
Apr 14, 2005·Annals of Surgical Oncology·Seema Rao GorlaMonica Morrow
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Jun 13, 2006·Japanese Journal of Clinical Oncology·Chisato NagataUNKNOWN Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
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Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lena U RosenbergCecilia Magnusson

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