Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2

The EMBO Journal
Amel AlqadahChiou-Fen Chuang

Abstract

Diversification of neuron classes is essential for functions of the olfactory system, but the underlying mechanisms that generate individual olfactory neuron types are only beginning to be understood. Here we describe a role of the highly conserved HMG-box transcription factor SOX-2 in postmitotic specification and alternative differentiation of the Caenorhabditis elegans AWC and AWB olfactory neurons. We show that SOX-2 partners with different transcription factors to diversify postmitotic olfactory cell types. SOX-2 functions cooperatively with the OTX/OTD transcription factor CEH-36 to specify an AWC "ground state," and functions with the LIM homeodomain factor LIM-4 to suppress this ground state and drive an AWB identity instead. Our findings provide novel insights into combinatorial codes that drive terminal differentiation programs in the nervous system and reveal a biological function of the deeply conserved Sox2 protein that goes beyond its well-known role in stem cell biology.

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Citations

Jan 9, 2016·Cell Cycle·Amel AlqadahChiou-Fen Chuang
Nov 26, 2015·Trends in Neurosciences·Paola Arlotta, Oliver Hobert
May 3, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Oliver Hobert
Nov 9, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Amel AlqadahChiou-Fen Chuang
Mar 31, 2017·Cellular and Molecular Life Sciences : CMLS·Yi-Wen HsiehChiou-Fen Chuang
Sep 25, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Amel AlqadahChiou-Fen Chuang
Nov 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Amel AlqadahChiou-Fen Chuang
Sep 22, 2019·International Journal of Molecular Sciences·Sara MercurioSilvia K Nicolis
Aug 28, 2021·Nature Reviews. Neuroscience·Oliver Hobert

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