PMID: 8956984Jan 1, 1996Paper

Postmortem distribution pattern of morphine and morphine glucuronides in heroin overdose

International Journal of Legal Medicine
G SkoppR Aderjan

Abstract

The postmortem distribution of morphine and its metabolites was investigated in four cases of heroin overdose to evaluate some of the factors that influence intravasal blood concentrations. Variables included were the chemical stability of morphine conjugates, hemoconcentration, incomplete distribution of the drug and diffusion processes. Blood samples from different sampling sites including the aorta, the infra- and suprarenal portion of the inferior vena cava, the superior vena cava, the femoral and subclavian veins, and the right and left ventricles were examined for morphine, morphine-3-glucuronide and morphine-6-glucuronide, hematocrit and water content. Drug concentrations were determined by HPLC based on the native fluorescence of the analytes. Morphine glucuronides proved to be stable for a time period of 72 h. The water content ranged from 65 to 83% and hematocrit values from 25 to 75%, and were seen as contributory factors to the dramatic differences observed for drug concentrations from different sampling sites. The differences could neither be attributed to incomplete distribution during life-time nor to a diffusion process following the different distribution volumes of morphine and its conjugates. A definite relat...Continue Reading

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Citations

Oct 21, 1998·Therapeutic Drug Monitoring·R E Aderjan, G Skopp
May 2, 2014·The American Journal of Forensic Medicine and Pathology·Veronica M Hargrove, D Kimberley Molina
Aug 30, 2018·Drug Testing and Analysis·Peter D MaskellGiorgia De Paoli
Apr 8, 2009·International Journal of Legal Medicine·Nerea FerreirósWolfgang Weinmann
Jul 10, 2010·Toxicology Mechanisms and Methods·R J Dinis-OliveiraT Magalhães
May 1, 2013·The American Journal of Forensic Medicine and Pathology·D Kimberley Molina, Veronica M Hargrove
Jul 2, 2016·Journal of Forensic Sciences·Eric LemairePhilippe Boxho
Apr 13, 2015·International Journal of Legal Medicine·Peter D MaskellL Nitin Seetohul
Feb 7, 2018·Journal of Analytical Toxicology·Cecilie Hasselø ThaulowVigdis Vindenes

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