Postmortem microfocus computed tomography for noninvasive autopsies: experience in >250 human fetuses.

American Journal of Obstetrics and Gynecology
Susan C ShelmerdineOwen J Arthurs

Abstract

Noninvasive imaging autopsy alternatives for fetuses weighing <500 grams are limited. Microfocus computed tomography has been reported as a viable option in small case series with the potential to avoid an invasive autopsy. Implementation of postmortem microfocus computed tomography in a large cohort as part of routine clinical service has yet been unreported, and realistic "autopsy prevention rates" are unknown. This study aimed to describe the range of abnormalities detectable on fetal microfocus computed tomography in a clinical setting and additional findings identified on the antenatal ultrasound and to estimate the invasive autopsy avoidance rate (ie, cases in which imaging was sufficient to deem autopsy unnecessary). A prospective observational case series of all fetuses referred for microfocus computed tomography imaging at a single institution was conducted for 3 years (2016-2019). Imaging was reported by 2 pediatric radiologists before autopsy, with "decision to proceed" based on the specialist perinatal pathologists' judgment and parental consent. Agreement rates between microfocus computed tomography and antenatal ultrasound were evaluated, and where feasible, diagnostic accuracy for microfocus computed tomography w...Continue Reading

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Citations

Mar 5, 2021·American Journal of Obstetrics and Gynecology·Barbara UlmVanessa Berger-Kulemann
Apr 16, 2021·Nature Protocols·Ian C SimcockOwen J Arthurs
Jul 16, 2021·Insights Into Imaging·Susan C ShelmerdineOwen J Arthurs
Jul 19, 2021·Radiography·I C SimcockO J Arthurs

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