Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning

Nature Communications
Cécile JacovettiRomano Regazzi

Abstract

Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process involving major modifications in gene expression programs. Here we show that β-cell maturation is associated with changes in microRNA expression induced by the nutritional transition that occurs at weaning. When mimicked in newborn islet cells, modifications in the level of specific microRNAs result in a switch in the expression of metabolic enzymes and cause the acquisition of glucose-induced insulin release. Our data suggest microRNAs have a central role in postnatal β-cell maturation and in the determination of adult functional β-cell mass. A better understanding of the events governing β-cell maturation may help understand why some individuals are predisposed to developing diabetes and could lead to new strategies for the treatment of this common metabolic disease.

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P RorsmanP O Berggren
Jan 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J GirardP Ferré
Jan 14, 2003·Experimental Biology and Medicine·Malathi SrinivasanMulchand S Patel
May 23, 2006·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Carolina Prado de França CarvalhoCarla Beatriz Collares-Buzato
Sep 7, 2007·Diabetes·Francis C LynnMichael S German
Nov 21, 2007·Trends in Endocrinology and Metabolism : TEM·Mugdha V JoglekarAnandwardhan A Hardikar
Dec 19, 2007·Biochemical and Biophysical Research Communications·Valia Bravo-EganaRicardo L Pastori
Sep 9, 2008·Trends in Endocrinology and Metabolism : TEM·Christopher J Nolan, Marc Prentki
Jan 24, 2009·Annals of the New York Academy of Sciences·Aldo RozzoMarjan Rupnik
Nov 7, 2009·PloS One·Kevin MillerManami Hara
Apr 9, 2010·Cell Metabolism·Chunyan GuJacqueline E Lee
Oct 29, 2010·Genome Biology·Simon Anders, Wolfgang Huber
Dec 31, 2010·Diabetologia·C Aguayo-MazzucatoS Bonner-Weir
May 25, 2011·Journal of Biomedical Informatics·Harsh DweepNorbert Gretz
Dec 7, 2011·Experimental Diabetes Research·Akadiri Yessoufou, Kabirou Moutairou
Jan 24, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Martin KöhlerPer-Olof Berggren
Mar 27, 2012·Biochemical and Biophysical Research Communications·Baocan WangJiangao Fan
Jun 30, 2012·The Journal of Clinical Endocrinology and Metabolism·Brigid E GreggChristopher J Rhodes
Jul 4, 2012·Circulation Research·Scot J MatkovichGerald W Dorn
Sep 7, 2012·Diabetes, Obesity & Metabolism·C GuayR Regazzi
Sep 20, 2012·Experimental Diabetes Research·Amitai D MandelbaumEran Hornstein
Sep 22, 2012·The Journal of Clinical Investigation·Cécile JacovettiRomano Regazzi
Nov 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yuanxin HuGerald W Dorn

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Citations

Oct 17, 2015·The Proceedings of the Nutrition Society·Romano RegazziCécile Jacovetti
Aug 29, 2016·Molecular and Cellular Endocrinology·Yaxi ChenXijie Yu
Mar 9, 2017·Genes & Development·Jennifer S E Liu, Matthias Hebrok
May 12, 2016·Cell Metabolism·Jun Shirakawa, Rohit N Kulkarni
Jan 26, 2017·The International Journal of Biochemistry & Cell Biology·Louise Torp Dalgaard, Lena Eliasson
Jan 20, 2018·American Journal of Physiology. Endocrinology and Metabolism·Peter A KroppMaureen Gannon
Dec 6, 2017·The Journal of Endocrinology·Mohammed BensellamD Ross Laybutt
Feb 6, 2018·Nature Communications·Sapna PuriMatthias Hebrok
Dec 7, 2018·The Journal of Endocrinology·Jose CasasnovasKok Lim Kua
Jul 3, 2019·The Journal of Clinical Investigation·Rami JaafarAnil Bhushan
Sep 4, 2019·The Journal of Clinical Investigation·Raphael ScharfmannOlivier Albagli
Oct 2, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Gladys Teitelman
Apr 14, 2016·American Journal of Physiology. Endocrinology and Metabolism·Charles ZhangSteven D Chessler
Dec 13, 2016·The Journal of Clinical Investigation·Benjamin N EdigerDoris A Stoffers
Jul 18, 2017·Diabetologia·Imène Sarah HenaouiRomano Regazzi
Mar 20, 2020·Cellular and Molecular Life Sciences : CMLS·Mathie TenenbaumAmar Abderrahmani
Feb 11, 2020·Frontiers in Endocrinology·Shan WanXijie Yu
Jun 30, 2019·Current Diabetes Reports·Sangeeta Dhawan, Rama Natarajan
Feb 19, 2020·Cardiovascular Diabetology·Marco WitkowskiUrsula Rauch
Jan 27, 2017·Frontiers in Genetics·Aida Martinez-SanchezMathieu Latreille
Mar 25, 2016·Acta Physiologica·S VienbergL T Dalgaard
Dec 20, 2017·Expert Opinion on Therapeutic Targets·Romano Regazzi
Feb 16, 2021·American Journal of Physiology. Endocrinology and Metabolism·Mario A MirandaHeather A Lawson
May 15, 2016·Biochimica Et Biophysica Acta·Claudiane Guay, Romano Regazzi
Mar 16, 2021·Frontiers in Endocrinology·Amanda Oakie, Maria Cristina Nostro
Apr 24, 2021·World Journal of Diabetes·Simon LecoutreChristophe Breton
May 26, 2021·Trends in Endocrinology and Metabolism : TEM·Matthew Wortham, Maike Sander
Apr 30, 2021·Endocrinology·Nivedita Seshadri, Christine A Doucette

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Datasets Mentioned

BETA
GSE61182

Methods Mentioned

BETA
PCR
fluorescence-activated cell sorting
immunoprecipitation
FACS
ELISA
transfection

Software Mentioned

R
Arraystar
Agilent GeneSpring GX
DESeq package
DESeq
DAVID

Related Concepts

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