Postnatal administration of allopregnanolone modifies glutamate release but not BDNF content in striatum samples of rats prenatally exposed to ethanol

BioMed Research International
R YunesR Cabrera

Abstract

Ethanol consumption during pregnancy may induce profound changes in fetal CNS development. We postulate that some of the effects of ethanol on striatal glutamatergic transmission and neurotrophin expression could be modulated by allopregnanolone, a neurosteroid modulator of GABAA receptor activity. We describe the acute pharmacological effect of allopregnanolone (65 μg/kg, s.c.) administered to juvenile male rats (day 21 of age) on the corticostriatal glutamatergic pathway, in both control and prenatally ethanol-exposed rats (two ip injections of 2.9 g/kg in 24% v/v saline solution on gestational day 8). Prenatal ethanol administration decreased the K(+)-induced release of glutamate regarding the control group. Interestingly, this effect was reverted by allopregnanolone. Regarding BDNF, allopregnanolone decreases the content of this neurotrophic factor in the striatum of control groups. However, both ethanol alone and ethanol plus allopregnanolone treated animals did not show any change regarding control values. We suggest that prenatal ethanol exposure may produce an alteration of GABAA receptors which blocks the GABA agonist-like effect of allopregnanolone on rapid glutamate release, thus disturbing normal neural transmission...Continue Reading

References

Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B Zimmerberg, R C Brown
Oct 24, 1998·Trends in Neurosciences·C A Altar, P S DiStefano
Jun 6, 2000·Brain Research. Developmental Brain Research·M B HeatonD W Walker
Dec 14, 2002·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Rahul T KhistiA Leslie Morrow
Jun 30, 2004·Addiction Biology·John W Olney
Apr 29, 2006·American Journal of Obstetrics and Gynecology·Laura TosoCatherine Y Spong
May 18, 2010·Brain Research Reviews·Joana Gil-MohapelBrian R Christie
Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuxiang XieBaoji Xu
Dec 2, 2010·European Journal of Pharmacology·Hye-Mi ParkIl-Sung Jang
Mar 9, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Alexandre E Medina
Mar 19, 2011·Experimental Neurology·María Paula AronneAlicia Brusco
May 18, 2011·Alcoholism, Clinical and Experimental Research·Alexa NardelliChristian Beaulieu
Jun 28, 2011·Neuroscience·R C MelcangiL M Garcia-Segura
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dong Hyun KimJong Hoon Ryu
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui YuZhe-Yu Chen
Aug 3, 2013·Alcoholism, Clinical and Experimental Research·Jason B CookA Leslie Morrow

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Jan 16, 2016·Oxidative Medicine and Cellular Longevity·Ji JiaTingting Huo

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