Postnatal changes in serotonergic innervation to the hippocampus of methyl-CpG-binding protein 2-null mice

Neuroscience
K IsodaH Hosoi

Abstract

Rett syndrome is a progressive neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MeCP2) gene. Previous reports have revealed serotonergic function to be altered in the medullas of patients with Rett syndrome and in an animal model of the disease. However, it has remained unclear whether a genetic loss of MeCP2 disrupts serotonergic innervation to the forebrain. In this study, we measured levels of monoamines by high-performance liquid chromatography with electrochemical detection in selected regions of the forebrains of Mecp2-null mice (Mecp2-/y) and wild-type mice (Mecp2+/y) on postnatal day (P) 14, P28, P42 and P56. The levels of hippocampal serotonin (5-HT) and its main metabolite, 5-hydroxyindoleacetic acid (5-HIAA), were significantly lower in Mecp2-null mice than in age-matched wild-type mice on P28, P42 and P56. Immunohistochemical analysis revealed a loss of 5-HT-immunoreactive fibers in the Mecp2-null hippocampus on P56. By contrast, in the raphe region of Mecp2-null mice, there were significant decreases in 5-HT and noradrenaline levels, but these differences later disappeared and there was no change in the number of 5-HT-immunoreactive neuronal cell bodies. Furthermore, we conducted...Continue Reading

References

Jan 1, 1989·Annals of Neurology·H Y ZoghbiA K Percy
Dec 9, 1998·Acta Neuropathologica·A NishimuraM Kawata
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W E LyonsL Tessarollo
May 23, 2000·Annals of Medicine·M C BuhotL Segu
May 29, 2000·Current Opinion in Genetics & Development·I B Van den Veyver, H Y Zoghbi
May 30, 2001·Brain & Development·A M KerrM Segawa
Dec 12, 2001·Brain & Development·Y Nomura
Dec 12, 2001·Brain & Development·D D Armstrong
Nov 29, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Rebecca H MountHilary Cass
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Charles ViemariGérard Hilaire
Apr 19, 2007·The European Journal of Neuroscience·Jean-Christophe RouxLaurent Villard
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dag H YasuiJanine M Lasalle
May 27, 2008·Brain Research·Efrain C Azmitia, Ralph Nixon

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Citations

May 26, 2011·BMC Neuroscience·Nicolas PanayotisJean-Christophe Roux
Jan 18, 2011·Experimental Biology and Medicine·Gaston CalfaLucas Pozzo-Miller
Jul 5, 2011·Annual Review of Cell and Developmental Biology·Jacky GuyAdrian Bird
Nov 22, 2011·Behavioural Brain Research·Antonio TrabalzaArturo Bevilacqua
May 1, 2015·Frontiers in Behavioral Neuroscience·Bianca De FilippisGiovanni Laviola
Jul 28, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sebastian P FernandezPatricia Gaspar
Apr 8, 2011·Journal of Neurophysiology·Miriam KronMichael Müller

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