Postnatal changes in the expression of serotonin 2A receptors in various brain stem nuclei of the rat.

Journal of Applied Physiology
Q Liu, M T Wong-Riley

Abstract

Previously, we reported a critical period [around postnatal day (P) 12-13 in the rat] in respiratory network development when distinct neurochemical, metabolic, and physiological changes occur. Since serotonin 2A (5-HT(2A)) receptors play an important role in respiratory modulation, we hypothesized that they may undergo developmental adjustments during the critical period. Semi-quantitative immunohistochemical analyses were conducted in labeled neurons in a number of brain stem nuclei with or without known respiratory functions from P2 to P21 in rats. Our data indicate that the expressions of 5-HT(2A) receptors in neurons of the pre-Bötzinger complex, the nucleus ambiguus, and the hypoglossal nucleus were maintained within a relatively narrow range between P2 and P21, with a dip at P3-P4 and a significant reduction only at P12. This change was not observed in the nonrespiratory cuneate nucleus. These results suggest that reduced expressions of 5-HT(2A) receptors at P12 contributes to neurochemical imbalance within brain stem respiratory nuclei at that time and may be involved in decreased hypoxic ventilatory response at this critical period of development.

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Citations

Jun 26, 2013·Respiratory Physiology & Neurobiology·Qiuli Liu, Margaret T T Wong-Riley
Dec 3, 2013·Anatomical Science International·Hiroyuki ItoKorehito Yamanouchi
Jun 12, 2012·Respiratory Physiology & Neurobiology·Margaret T T Wong-RileyXiu-ping Gao
Feb 14, 2009·Autonomic Neuroscience : Basic & Clinical·David S Paterson, Ryan Darnall
Feb 27, 2018·The Journal of Physiology·Luis Gustavo A PatroneLuciane H Gargaglioni
Jan 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B M GajdaW K Milsom
Nov 8, 2011·Journal of Neural Engineering·Christopher FietkiewiczChristopher G Wilson
Jan 4, 2020·Respiratory Physiology & Neurobiology·Sarah A BeyelerAdrianne G Huxtable
Feb 16, 2021·Respiratory Physiology & Neurobiology·Ryan J Sprenger, William K Milsom
Aug 19, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard L SpinieliKevin J Cummings

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